Fig. 2
From: Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles
Structure of a single layer within a mature αS fibril. Based on the CryoEM structure published by Li et al [26] displaying formation of the ‘Greek Key’ topology with rotational symmetry about the axis of the fibril. The early onset mutations (E46K, H50Q, G51D/E, A53T) are highlighted (pink) in addition to three key electrostatic interactions that are perturbed in early onset PD (K58-E61, E46-K80 and K45/H50-E57)