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Table 1 Comparison of the effects of age of onset [106], lipid binding [69, 70, 106] and fibril growth rates [69, 70, 106] of the different early onset mutations in the SNCA gene as compared to the wild-type protein. An additional mutation A53V has also been reported [66]. The mutations listed have additionally been described as leading to different clinical and pathological features [107]

From: Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles