Fig. 1From: Impaired dopamine metabolism in Parkinson’s disease pathogenesisDopamine catabolism. In dopaminergic neurons, DA catabolism starts with deamination by MAO to generate DOPAL. The aldehyde moiety is then converted to the carboxyl group of DOPAC by ALDHs. A smaller fraction of DOPAL aldehyde is converted to the hydroxyl group of DOPET by ALR/ARs (thinner arrow)Back to article page