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Table 2 Clinical Diagnoses of 227 Patients with a Pathologic Diagnosis of Pure AD. More than a third of pathologic AD cases on the Mayo Clinic Brain Bank from 2007 to 2016 were not expected to have AD. Plus sign (+) in the column on clinical diagnosis indicates additional clinical diagnoses are supported. Bold indicates significance differences from the pure AD cases (Student t-Test, p < 0.01)

From: The neuropathological diagnosis of Alzheimer’s disease

Clinical Dx Cases (n) Age (yr) Brain (g) Braak Thal
AD 109 77.3 ± 11.2 1061 ± 163 5.5 ± 0.7 4.7 ± 0.7
AD+ 35 73.0 ± 8.5 1069 ± 138 5.6 ± 0.6 4.8 ± 0.5
LBD 16 80.9 ± 9.8 1073 ± 158 5.3 ± 0.6 4.5 ± 0.8
CBS 12 71.3 ± 7.4 1008 ± 169 5.9 ± 0.3 5.0 ± 0.0
FTD 10 66.4 ± 8.9 1103 ± 128 5.5 ± 1.1 4.9 ± 0.4
Aphasia 6 72.2 ± 7.1 940 ± 109 5.9 ± 0.2 4.8 ± 0.4
Other 21 78.2 ± 10.3 1132 ± 155 5.4 ± 0.8 5.0 ± 0.0
MCI 11 87.7 ± 6.9 1162 ± 136 4.9 ± 0.6 5.0 ± 0.0
Normal 7 85.9 ± 6.6 1251 ± 120 4.7 ± 0.8 3.0 ± 0.0