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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

Fig. 2

PLX treatment significantly decreases microglia numbers in the mouse striatum. a Microglia marker (Iba-1) protein as determined by western blotting shows significant depletion in striatal brain homogenates; n = 6 control, n = 8 PLX. b The density of microglia was reduced in striatal brain tissue stained for Iba-1. Quantification is shown above the images; n = 8 control, n = 8 PLX. ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001. The error bars represent S.E.M. c Representative images of microglia through the striatum that contained the neural graft used for quantifying microglia density. The insert images are higher magnification taken from the same brain section; high magnification image scale bars = 500 μm; low magnification image scale bars = 50 μm. d Representative images of microglia morphology from the contralateral striatum and ipsilateral striatum. Quantification of microglia morphology (area/perimeter) is shown below the images; n = 10 control, n = 10 PLX. ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001. The error bars represent S.E.M.

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