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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

Fig. 3

Fewer microglia following PLX treatment increased α-syn cell-to-cell transfer within the graft. a Confocal orthogonal reconstructions of grafted mouse TH-positive neurons (red) displaying intracellular puncta of transferred huα-syn (white); DAPI stain (blue) indicates nuclei. White box outlines cell of interest containing huα-syn puncta. The percentage of TH-positive neurons containing huα-syn. Control (circles) n = 18, PLX (squares) n = 10. * = p < 0.05. The error bars represent S.E.M. b Confocal 3D reconstructions of Iba-1 positive microglia (green), grafted mouse TH-positive neurons (red) displaying intracellular puncta of transferred huα-syn (white); DAPI stain (blue) indicates nuclei. White box outlines cell of interest containing huα-syn puncta. White arrows indicate huα-syn punctae. The percentage of Iba-1-positive microglia containing huα-syn. Control (circles) n = 18, PLX (squares) n = 10. The error bars represent S.E.M.

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