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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

Fig. 7

Cell-to-cell transfer of hu-αsyn into Iba-1-positive and TH-positive cells following microglia activation. a Orthogonal confocal reconstructions of microglial cells (Iba-1, green) containing intracellular puncta of hu-αsyn (red); nuclei are stained blue. White box outlines cell of interest containing huα-syn puncta. The percentage of Iba-1-positive microglia containing hu-αsyn (control, n = 20; LPS, n = 20; IL-4, n = 23). * = p < 0.05; error bars represent S.E.M. b Orthogonal confocal 3D reconstructions of TH-positive dopaminergic neurons (green) containing intracellular puncta of hu-αsyn (red); nuclei are stained blue. White box outlines cell of interest containing huα-syn puncta. White arrows indicate huα-syn punctae. The percentage of TH-positive neurons containing hu-αsyn (control, n = 20; LPS, n = 20; IL-4, n = 23). * = p < 0.05; error bars represent S.E.M.

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