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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Glucocerebrosidase and its relevance to Parkinson disease

Fig. 1

Simplified diagram of the synthesis and trafficking of GCase in a functional cell. 1) GBA1, the gene coding for GCase, is transcribed into mRNA that is then transported out of the nucleus to the ER. 2) GCase is synthesized in the ER, where it binds to the protein LIMP2 in the favorable neutral pH of the cytoplasm. 3) LIMP2 transfers GCase through the Golgi. 4) GCase is then transferred to a late endosome. 5) When the late endosome fuses with a lysosome to form an autolysosome, LIMP2 disengages from GCase due to the decrease in pH. In the lysosome, GCase is activated by SAPC. GCase actively hydrolyzes its substrates GlcCer and GlcSph in this compartment

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