Fig. 1

Reduced GBA and GBA2 activities in substantia nigra of PD patients and with normal ageing. GBA and GBA2 β-glucosidase activities were measured using artificial 4-MU-substrate and the inhibitor NB-DGJ. Activity of GBA (a,b) and GBA2 (c,d) were determined in substantia nigra from control subjects and PD patients. PD patients identified as GBA mutation carriers are shown in grey (a,c). Data were analysed using Pearson correlation analysis (a,c) (n = 10 per group) and 2-way ANOVA (b,d) (n = 5 per cohort; * = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001). All p-values can be found in the Additional file 3. Bar graphs are presented as mean ± SEM