Fig. 2

Reduced lysosomal hydrolase activities in substantia nigra of PD patients. Lysosomal hydrolase activities were measured using artificial 4-MU-substrates. Activity of α-galactosidase (a,b), β-hexosaminidase (c,d), β-galactosidase (e,f) and neuraminidase (g,h) were determined in substantia nigra from control subjects and PD patients. PD patients identified as GBA mutation carriers are shown in grey (a,c,e,g). Data were analysed using Pearson correlation analysis (a,c,e,g) (n = 10 per group) and 2-way ANOVA (b,d,f,h) (n = 5 per cohort; * = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001). All p-values can be found in the Additional file 3. Bar graphs are presented as mean ± SEM