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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

Fig. 6

Increase in glucosylceramide and loss of gangliosides in substantia nigra from a second cohort of PD patients. Substantia nigra from control subjects (n = 5) and PD patients (n = 20) were used to determine GlcCer (a), LacCer (b) GM1a (c), GD1a (d), GD1b (e) and GT1b (f) levels with NP-HPLC (* = p < 0.05, unpaired t-test). g Comparison of total ganglioside levels (sum of GM1a, GD1a, GD1b and GT1b) in substantia nigra from control subjects and PD patients (** = p < 0.01, unpaired t-test). h Total GSL levels (sum of GlcCer + LacCer + GM1a + GD1a + GD1b + GT1b levels) in substantia nigra from control subjects and PD patients (* = p < 0.05, unpaired t-test). Data are presented as mean ± SEM

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Molecular Neurodegeneration

ISSN: 1750-1326