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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

Fig. 3

Deletion of NRBF2 enhances accumulation of APP-CTFs and Aβ42 in mouse hippocampus. a Expression of FL-APP, APP-CTFs in the hippocampus of 20-months-old WT (n = 6) and NRBF2-KO (n = 6) mice. The blots shown are representative of two separate experiments (b-e) Quantification of (a). The statistical significance was determined using two-tailed unpaired Student’s t-test. f ELISA analysis results of Aβ1–42 levels in hippocampus of 20- month-old WT (n = 3) and NRBF2-KO (n = 3) mice. The statistical significance was determined using two-tailed unpaired Student’s t-test. *p < 0.05, **p < 0.01, ****p < 0.0001

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