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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

Fig. 4

Transduction of NRBF2 carrying viruses into dorsal hippocampus rescues memory impairments and restores autophagy in NRBF2-KO mice. a Discrimination ratio obtained on testing day of OLT. b Freezing behavior recorded during CFC experiments. Results are mean ± SEM of 3–4 months old WT + mCherry (n = 14), WT + NRBF2 (n = 14), KO + mCherry (n = 16) and KO + NRBF2 (n = 18) mice. c Immunoblot (IB) analysis of p62 and LC3B. d-e Quantification of C. Results are mean ± SEM of 3–4 months old WT + mCherry (n = 11) and WT + NRBF2 (n = 12) KO + mCherry (n = 11) KO + NRBF2 (n = 11) mice. The statistical significance was determined using regular two-way ANOVA test followed by Bonferroni’s post-test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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