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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury

Fig. 2

Axonal degeneration (Gallyas silver) and neuroinflammation in the visual system after IA injury. a-d. Gallyas silver degeneration staining shows axonal pathology (black swellings, lines, trails, dots) 7 days after injury in the optic nerve (ON, a), optic tract (OT, b), and superior colliculus (SC, c). Sham tissues show no silver signal at the same time point (d). e-f. Neuroinflammatory responses are evident by the presence of hypertrophic IBA1 (+) microglia and microglial nodules in these sections prepared 7 days after injury. Note the striking selectivity of neuroinflammation in the visual system (optic nerve [ON] and optic tract [OT]) by comparing IBA1 (+) profiles in ON and OT to normal resting microglia in overlying hypothalamus. Scale bars: a-d, 100 μm; e, 80 μm; f, 150 μm

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Molecular Neurodegeneration

ISSN: 1750-1326