TY - JOUR AU - Humpel, C. PY - 2015 DA - 2015// TI - Organotypic brain slice cultures: a review JO - Neuroscience VL - 305 UR - https://doi.org/10.1016/j.neuroscience.2015.07.086 DO - 10.1016/j.neuroscience.2015.07.086 ID - Humpel2015 ER - TY - JOUR AU - Butovsky, O. AU - Jedrychowski, M. P. AU - Moore, C. S. AU - Cialic, R. AU - Lanser, A. J. AU - Gabriely, G. PY - 2014 DA - 2014// TI - Identification of a unique TGF-β-dependent molecular and functional signature in microglia JO - Nat Naurosci VL - 17 UR - https://doi.org/10.1038/nn.3599 DO - 10.1038/nn.3599 ID - Butovsky2014 ER - TY - JOUR AU - Arber, C. AU - Lovejoy, C. AU - Wray, S. PY - 2017 DA - 2017// TI - Stem cell models of Alzheimer's disease: progress and challenges JO - Alz Res Ther VL - 9 UR - https://doi.org/10.1186/s13195-017-0268-4 DO - 10.1186/s13195-017-0268-4 ID - Arber2017 ER - TY - JOUR AU - Fitzjohn, S. M. AU - Doherty, A. J. AU - Collingridge, G. L. PY - 2008 DA - 2008// TI - The use of the hippocampal slice preparation in the study of Alzheimer's disease JO - Eur J Pharm VL - 585 UR - https://doi.org/10.1016/j.ejphar.2008.02.077 DO - 10.1016/j.ejphar.2008.02.077 ID - Fitzjohn2008 ER - TY - JOUR AU - Gähwiler, B. H. PY - 1981 DA - 1981// TI - Organotypic monolayer cultures of nervous tissue JO - J Neurosci Methods VL - 4 UR - https://doi.org/10.1016/0165-0270(81)90003-0 DO - 10.1016/0165-0270(81)90003-0 ID - Gähwiler1981 ER - TY - JOUR AU - Stoppini, L. AU - Buchs, P. A. AU - Muller, D. PY - 1991 DA - 1991// TI - A simple method for organotypic cultures of nervous tissue JO - J Neurosci Methods VL - 37 UR - https://doi.org/10.1016/0165-0270(91)90128-M DO - 10.1016/0165-0270(91)90128-M ID - Stoppini1991 ER - TY - JOUR AU - Noraberg, J. AU - Poulsen, F. R. AU - Blaabjerg, M. AU - Kristensen, B. W. AU - Bonde, C. AU - Montero, M. PY - 2005 DA - 2005// TI - Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair JO - Curr Drug Targets CNS Neurol Disord VL - 4 UR - https://doi.org/10.2174/1568007054546108 DO - 10.2174/1568007054546108 ID - Noraberg2005 ER - TY - JOUR AU - Beach, R. L. AU - Bathgate, S. L. AU - Cotman, C. W. PY - 1982 DA - 1982// TI - Identification of cell types in rat hippocampal slices maintained in organotypic cultures JO - Dev Brain Res VL - 3 UR - https://doi.org/10.1016/0165-3806(82)90071-2 DO - 10.1016/0165-3806(82)90071-2 ID - Beach1982 ER - TY - JOUR AU - Bahr, B. A. PY - 1995 DA - 1995// TI - Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes JO - J Neurosci Res VL - 42 UR - https://doi.org/10.1002/jnr.490420303 DO - 10.1002/jnr.490420303 ID - Bahr1995 ER - TY - JOUR AU - Sieg, F. AU - Obst, K. AU - Gorba, T. AU - Riederer, B. AU - Pape, H. -. C. AU - Wahle, P. PY - 1998 DA - 1998// TI - Postnatal expression pattern of calcium-binding proteins in organotypic thalamic cultures and in the dorsal thalamus in vivo JO - Dev Brain Res VL - 110 UR - https://doi.org/10.1016/S0165-3806(98)00097-2 DO - 10.1016/S0165-3806(98)00097-2 ID - Sieg1998 ER - TY - JOUR AU - Daviaud, N. AU - Garbayo, E. AU - Lautram, N. AU - Franconi, F. AU - Lemaire, L. AU - Perez-Pinzon, M. PY - 2014 DA - 2014// TI - Modeling nigrostriatal degeneration in organotypic cultures, a new ex vivo model of Parkinson’s disease JO - Neuroscience VL - 256 UR - https://doi.org/10.1016/j.neuroscience.2013.10.021 DO - 10.1016/j.neuroscience.2013.10.021 ID - Daviaud2014 ER - TY - JOUR AU - Duff, K. AU - Noble, W. AU - Gaynor, K. AU - Matsuoka, Y. PY - 2002 DA - 2002// TI - Organotypic slice cultures from transgenic mice as disease model systems JO - J Mol Neurosci VL - 19 UR - https://doi.org/10.1385/JMN:19:3:317 DO - 10.1385/JMN:19:3:317 ID - Duff2002 ER - TY - JOUR AU - Croft, C. L. AU - Wade, M. A. AU - Kurbatskaya, K. AU - Mastrandreas, P. AU - Hughes, M. M. AU - Phillips, E. C. PY - 2017 DA - 2017// TI - Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures JO - Cell Death Dis VL - 8 UR - https://doi.org/10.1038/cddis.2017.97 DO - 10.1038/cddis.2017.97 ID - Croft2017 ER - TY - JOUR AU - Staal, J. A. AU - Alexander, S. R. AU - Liu, Y. AU - Dickson, T. D. AU - Vickers, J. C. PY - 2011 DA - 2011// TI - Characterization of cortical neuronal and glial alterations during culture of Organotypic whole brain slices from neonatal and mature mice JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0022040 DO - 10.1371/journal.pone.0022040 ID - Staal2011 ER - TY - JOUR AU - Ullrich, C. AU - Daschil, N. AU - Humpel, C. PY - 2011 DA - 2011// TI - Organotypic vibrosections: novel whole sagittal brain cultures JO - J Neurosci Methods VL - 201 UR - https://doi.org/10.1016/j.jneumeth.2011.07.021 DO - 10.1016/j.jneumeth.2011.07.021 ID - Ullrich2011 ER - TY - JOUR AU - Koh, J. Y. AU - Choi, D. W. PY - 1987 DA - 1987// TI - Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay JO - J Neurosci Methods VL - 20 UR - https://doi.org/10.1016/0165-0270(87)90041-0 DO - 10.1016/0165-0270(87)90041-0 ID - Koh1987 ER - TY - JOUR AU - Noraberg, J. AU - Kristensen, B. W. AU - Zimmer, J. PY - 1999 DA - 1999// TI - Markers for neuronal degeneration in organotypic slice cultures JO - Brain Res Brain Res Protoc VL - 3 UR - https://doi.org/10.1016/S1385-299X(98)00050-6 DO - 10.1016/S1385-299X(98)00050-6 ID - Noraberg1999 ER - TY - JOUR AU - Simoni, A. AU - Griesinger, C. B. AU - Edwards, F. A. PY - 2003 DA - 2003// TI - Development of rat CA1 neurones in acute versus organotypic slices: role of experience in synaptic morphology and activity JO - J Physiol VL - 550 UR - https://doi.org/10.1113/jphysiol.2003.039099 DO - 10.1113/jphysiol.2003.039099 ID - Simoni2003 ER - TY - JOUR AU - Xiang, Z. AU - Hrabetova, S. AU - Moskowitz, S. I. AU - Casaccia-Bonnefil, P. AU - Young, S. R. AU - Nimmrich, V. C. PY - 2000 DA - 2000// TI - Long-term maintenance of mature hippocampal slices in vitro JO - J Neurosci Methods VL - 98 UR - https://doi.org/10.1016/S0165-0270(00)00197-7 DO - 10.1016/S0165-0270(00)00197-7 ID - Xiang2000 ER - TY - JOUR AU - Humpel, C. PY - 2015 DA - 2015// TI - Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques JO - Front Aging Neurosci VL - 7 UR - https://doi.org/10.3389/fnagi.2015.00047 DO - 10.3389/fnagi.2015.00047 ID - Humpel2015 ER - TY - JOUR AU - Daria, A. n. n. a. AU - Colombo, A. l. e. s. s. i. o. AU - Llovera, G. e. m. m. a. AU - Hampel, H. e. i. k. e. AU - Willem, M. i. c. h. a. e. l. AU - Liesz, A. r. t. h. u. r. AU - Haass, C. h. r. i. s. t. i. a. n. AU - Tahirovic, S. a. b. i. n. a. PY - 2016 DA - 2016// TI - Young microglia restore amyloid plaque clearance of aged microglia JO - The EMBO Journal VL - 36 UR - https://doi.org/10.15252/embj.201694591 DO - 10.15252/embj.201694591 ID - Daria2016 ER - TY - JOUR AU - Andersson, M. AU - Avaliani, N. AU - Svensson, A. AU - Wickham, J. AU - Pinborg, L. H. AU - Jespersen, B. PY - 2016 DA - 2016// TI - Optogenetic control of human neurons in organotypic brain cultures JO - Sci Rep VL - 6 UR - https://doi.org/10.1038/srep24818 DO - 10.1038/srep24818 ID - Andersson2016 ER - TY - JOUR AU - Eugène, E. AU - Cluzeaud, F. AU - Cifuentes-Diaz, C. AU - Fricker, D. AU - Duigou, C. AU - Clemenceau, S. PY - 2014 DA - 2014// TI - An organotypic brain slice preparation from adult patients with temporal lobe epilepsy JO - J Neurosci Methods VL - 235 UR - https://doi.org/10.1016/j.jneumeth.2014.07.009 DO - 10.1016/j.jneumeth.2014.07.009 ID - Eugène2014 ER - TY - JOUR AU - Verwer, R. W. H. AU - Baker, R. E. AU - Boiten, E. F. M. AU - Dubelaar, E. J. G. AU - Ginkel, C. J. M. AU - Sluiter, A. A. PY - 2003 DA - 2003// TI - Post-mortem brain tissue cultures from elderly control subjects and patients with a neurodegenerative disease JO - Exp Gerontol VL - 38 UR - https://doi.org/10.1016/S0531-5565(02)00154-7 DO - 10.1016/S0531-5565(02)00154-7 ID - Verwer2003 ER - TY - JOUR AU - Lyman, W. D. AU - Tricoche, M. AU - Hatch, W. C. AU - Kress, Y. AU - Chiu, F. C. AU - Rashbaum, W. K. PY - 1991 DA - 1991// TI - Human fetal central nervous system organotypic cultures JO - Brain Res Dev Brain Res VL - 60 UR - https://doi.org/10.1016/0165-3806(91)90044-J DO - 10.1016/0165-3806(91)90044-J ID - Lyman1991 ER - TY - JOUR AU - Schwarz, N. AU - Uysal, B. AU - Welzer, M. AU - Bahr, J. C. AU - Layer, N. AU - Löffler, H. PY - 2019 DA - 2019// TI - Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease JO - eLife. VL - 8 UR - https://doi.org/10.7554/eLife.48417 DO - 10.7554/eLife.48417 ID - Schwarz2019 ER - TY - JOUR AU - Soares, C. AU - Lee, K. F. H. AU - Nassrallah, W. AU - Béïque, J. -. C. PY - 2013 DA - 2013// TI - Differential subcellular targeting of glutamate receptor subtypes during homeostatic synaptic plasticity JO - J Neurosci VL - 33 UR - https://doi.org/10.1523/JNEUROSCI.1873-13.2013 DO - 10.1523/JNEUROSCI.1873-13.2013 ID - Soares2013 ER - TY - JOUR AU - Ito, S. AU - Yeh, F. -. C. AU - Hiolski, E. AU - Rydygier, P. AU - Gunning, D. E. AU - Hottowy, P. PY - 2014 DA - 2014// TI - Large-scale, high-resolution multielectrode-Array recording depicts functional network differences of cortical and hippocampal cultures JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0105324 DO - 10.1371/journal.pone.0105324 ID - Ito2014 ER - TY - JOUR AU - Croft, C. L. AU - Cruz, P. E. AU - Ryu, D. H. AU - Ceballos-Diaz, C. AU - Strang, K. H. AU - Woody, B. M. PY - 2019 DA - 2019// TI - rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies JO - J Exp Med VL - 216 UR - https://doi.org/10.1084/jem.20182184 DO - 10.1084/jem.20182184 ID - Croft2019 ER - TY - JOUR AU - Rio, J. A. AU - Heimrich, B. AU - Soriano, E. AU - Schwegler, H. AU - Frotscher, M. PY - 1991 DA - 1991// TI - Proliferation and differentiation of glial fibrillary acidic protein-immunoreactive glial cells in organotypic slice cultures of rat hippocampus JO - Neuroscience VL - 43 ID - Rio1991 ER - TY - JOUR AU - Hailer, N. P. AU - Järhult, J. D. AU - Nitsch, R. PY - 1996 DA - 1996// TI - Resting microglial cells in vitro: analysis of morphology and adhesion molecule expression in organotypic hippocampal slice cultures JO - Glia VL - 18 UR - https://doi.org/3.0.CO;2-S DO - 3.0.CO;2-S ID - Hailer1996 ER - TY - JOUR AU - Hutter-Schmid, B. AU - Kniewallner, K. AU - Humpel, C. PY - 2015 DA - 2015// TI - Organotypic brain slice cultures as a model to study angiogenesis of brain vessels JO - Front Cell Dev Biol VL - 3 UR - https://doi.org/10.3389/fcell.2015.00052 DO - 10.3389/fcell.2015.00052 ID - Hutter-Schmid2015 ER - TY - JOUR AU - Finley, M. AU - Fairman, D. AU - Liu, D. AU - Li, P. AU - Wood, A. AU - Cho, S. PY - 2004 DA - 2004// TI - Functional validation of adult hippocampal organotypic cultures as an in vitro model of brain injury JO - Brain Res VL - 1001 UR - https://doi.org/10.1016/j.brainres.2003.12.009 DO - 10.1016/j.brainres.2003.12.009 ID - Finley2004 ER - TY - JOUR AU - Cho, S. AU - Wood, A. AU - Bowlby, M. R. PY - 2007 DA - 2007// TI - Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics JO - Curr Neuropharmacol VL - 5 UR - https://doi.org/10.2174/157015907780077105 DO - 10.2174/157015907780077105 ID - Cho2007 ER - TY - JOUR AU - Mielke, J. G. AU - Comas, T. AU - Woulfe, J. AU - Monette, R. AU - Chakravarthy, B. AU - Mealing, G. A. R. PY - 2005 DA - 2005// TI - Cytoskeletal, synaptic, and nuclear protein changes associated with rat interface organotypic hippocampal slice culture development JO - Dev Brain Res VL - 160 UR - https://doi.org/10.1016/j.devbrainres.2005.09.009 DO - 10.1016/j.devbrainres.2005.09.009 ID - Mielke2005 ER - TY - JOUR AU - Croft, C. L. AU - Noble, W. PY - 2018 DA - 2018// TI - Preparation of organotypic brain slice cultures for the study of Alzheimer's disease JO - F1000Res VL - 7 UR - https://doi.org/10.12688/f1000research.14500.2 DO - 10.12688/f1000research.14500.2 ID - Croft2018 ER - TY - JOUR AU - Croft, C. L. AU - Kurbatskaya, K. AU - Hanger, D. P. AU - Noble, W. PY - 2017 DA - 2017// TI - Inhibition of glycogen synthase kinase-3 by BTA-EG (4) reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer’s disease JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/s41598-017-07906-1 DO - 10.1038/s41598-017-07906-1 ID - Croft2017 ER - TY - JOUR AU - Harwell, C. S. AU - Coleman, M. P. PY - 2016 DA - 2016// TI - Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice JO - Mol Neurodegener VL - 11 UR - https://doi.org/10.1186/s13024-016-0110-7 DO - 10.1186/s13024-016-0110-7 ID - Harwell2016 ER - TY - JOUR AU - Dawson, T. M. AU - Golde, T. E. AU - Lagier-Tourenne, C. PY - 2018 DA - 2018// TI - Animal models of neurodegenerative diseases JO - Nat Neurosci VL - 21 UR - https://doi.org/10.1038/s41593-018-0236-8 DO - 10.1038/s41593-018-0236-8 ID - Dawson2018 ER - TY - JOUR AU - Selkoe, D. J. AU - Hardy, J. PY - 2016 DA - 2016// TI - The amyloid hypothesis of Alzheimer's disease at 25 years JO - EMBO Mol Med VL - 8 UR - https://doi.org/10.15252/emmm.201606210 DO - 10.15252/emmm.201606210 ID - Selkoe2016 ER - TY - JOUR AU - Golde, T. E. AU - Borchelt, D. R. AU - Giasson, B. I. AU - Lewis, J. PY - 2013 DA - 2013// TI - Thinking laterally about neurodegenerative proteinopathies JO - J Clin Invest VL - 123 UR - https://doi.org/10.1172/JCI66029 DO - 10.1172/JCI66029 ID - Golde2013 ER - TY - JOUR AU - Malouf, A. T. PY - 1992 DA - 1992// TI - Effect of beta amyloid peptides on neurons in hippocampal slice cultures JO - Neurobiol Aging VL - 13 UR - https://doi.org/10.1016/0197-4580(92)90054-2 DO - 10.1016/0197-4580(92)90054-2 ID - Malouf1992 ER - TY - JOUR AU - Hellwig, S. AU - Masuch, A. AU - Nestel, S. AU - Katzmarski, N. AU - Meyer-Luehmann, M. AU - Biber, K. PY - 2015 DA - 2015// TI - Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures JO - Sci Rep VL - 5 UR - https://doi.org/10.1038/srep14624 DO - 10.1038/srep14624 ID - Hellwig2015 ER - TY - JOUR AU - Braithwaite, S. P. AU - Schmid, R. S. AU - He, D. N. AU - Sung, M. -. L. A. AU - Cho, S. AU - Resnick, L. PY - 2010 DA - 2010// TI - Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease JO - Neurobiol Dis VL - 39 UR - https://doi.org/10.1016/j.nbd.2010.04.015 DO - 10.1016/j.nbd.2010.04.015 ID - Braithwaite2010 ER - TY - JOUR AU - Novotny, R. AU - Langer, F. AU - Mahler, J. AU - Skodras, A. AU - Vlachos, A. AU - Wegenast-Braun, B. M. PY - 2016 DA - 2016// TI - Conversion of synthetic Aβ to in vivo active seeds and amyloid plaque formation in a hippocampal slice culture model JO - J Neurosci VL - 36 UR - https://doi.org/10.1523/JNEUROSCI.0258-16.2016 DO - 10.1523/JNEUROSCI.0258-16.2016 ID - Novotny2016 ER - TY - JOUR AU - Terry, R. D. AU - Masliah, E. AU - Salmon, D. P. AU - Butters, N. AU - DeTeresa, R. AU - Hill, R. PY - 1991 DA - 1991// TI - Physical basis of cognitive alterations in alzheimer's disease: synapse loss is the major correlate of cognitive impairment JO - Ann Neurol VL - 30 UR - https://doi.org/10.1002/ana.410300410 DO - 10.1002/ana.410300410 ID - Terry1991 ER - TY - JOUR AU - Masliah, E. AU - Mallory, M. AU - Alford, M. AU - DeTeresa, R. AU - Hansen, L. A. AU - McKeel, D. W. PY - 2001 DA - 2001// TI - Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease JO - Neurology VL - 56 UR - https://doi.org/10.1212/WNL.56.1.127 DO - 10.1212/WNL.56.1.127 ID - Masliah2001 ER - TY - JOUR AU - Wirths, O. AU - Bayer, T. A. PY - 2010 DA - 2010// TI - Neuron loss in transgenic mouse models of Alzheimer's disease JO - Int J Alz Dis VL - 2010 ID - Wirths2010 ER - TY - JOUR AU - Gomez-Isla, T. AU - Hollister, R. AU - West, H. AU - Mui, S. AU - Growdon, J. H. AU - Petersen, R. C. PY - 1997 DA - 1997// TI - Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease JO - Ann Neurol VL - 41 UR - https://doi.org/10.1002/ana.410410106 DO - 10.1002/ana.410410106 ID - Gomez-Isla1997 ER - TY - JOUR AU - Iqbal, K. AU - Liu, F. AU - Gong, C. -. X. AU - Grundke-Iqbal, I. PY - 2010 DA - 2010// TI - Tau in alzheimer disease and related Tauopathies JO - Curr Alz Res VL - 7 UR - https://doi.org/10.2174/156720510793611592 DO - 10.2174/156720510793611592 ID - Iqbal2010 ER - TY - JOUR AU - Kovacs, G. G. PY - 2015 DA - 2015// TI - Invited review: neuropathology of tauopathies: principles and practice JO - Neuropathol App Neurobiol VL - 41 UR - https://doi.org/10.1111/nan.12208 DO - 10.1111/nan.12208 ID - Kovacs2015 ER - TY - JOUR AU - Hanger, D. P. AU - Anderton, B. H. AU - Noble, W. PY - 2009 DA - 2009// TI - Tau phosphorylation: the therapeutic challenge for neurodegenerative disease JO - Trends Mol Med VL - 15 UR - https://doi.org/10.1016/j.molmed.2009.01.003 DO - 10.1016/j.molmed.2009.01.003 ID - Hanger2009 ER - TY - JOUR AU - Lewis, J. AU - McGowan, E. AU - Rockwood, J. AU - Melrose, H. AU - Nacharaju, P. AU - Slegtenhorst, M. PY - 2000 DA - 2000// TI - Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein JO - Nat Genet VL - 25 UR - https://doi.org/10.1038/78078 DO - 10.1038/78078 ID - Lewis2000 ER - TY - JOUR AU - Andorfer, C. AU - Kress, Y. AU - Espinoza, M. AU - Silva, R. AU - Tucker, K. L. AU - Barde, Y. -. A. PY - 2003 DA - 2003// TI - Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms JO - J Neurochem VL - 86 UR - https://doi.org/10.1046/j.1471-4159.2003.01879.x DO - 10.1046/j.1471-4159.2003.01879.x ID - Andorfer2003 ER - TY - JOUR AU - Oddo, S. AU - Caccamo, A. AU - Kitazawa, M. AU - Tseng, B. P. AU - LaFerla, F. M. PY - 2003 DA - 2003// TI - Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer’s disease JO - Neurobiol Aging VL - 24 UR - https://doi.org/10.1016/j.neurobiolaging.2003.08.012 DO - 10.1016/j.neurobiolaging.2003.08.012 ID - Oddo2003 ER - TY - JOUR AU - Oddo, S. AU - Caccamo, A. AU - Shepherd, J. D. AU - Murphy, M. P. AU - Golde, T. E. AU - Kayed, R. PY - 2003 DA - 2003// TI - Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction JO - Neuron VL - 39 UR - https://doi.org/10.1016/S0896-6273(03)00434-3 DO - 10.1016/S0896-6273(03)00434-3 ID - Oddo2003 ER - TY - JOUR AU - Pooler, A. M. AU - Polydoro, M. AU - Wegmann, S. AU - Nicholls, S. B. AU - Spires-Jones, T. L. AU - Hyman, B. T. PY - 2013 DA - 2013// TI - Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets JO - Alz Res Ther VL - 5 UR - https://doi.org/10.1186/alzrt214 DO - 10.1186/alzrt214 ID - Pooler2013 ER - TY - JOUR AU - Mocanu, M. -. M. AU - Nissen, A. AU - Eckermann, K. AU - Khlistunova, I. AU - Biernat, J. AU - Drexler, D. PY - 2008 DA - 2008// TI - The potential for β-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous tau in inducible mouse models of Tauopathy JO - J Neurosci VL - 28 UR - https://doi.org/10.1523/JNEUROSCI.2824-07.2008 DO - 10.1523/JNEUROSCI.2824-07.2008 ID - Mocanu2008 ER - TY - JOUR AU - Messing, L. AU - Decker, J. M. AU - Joseph, M. AU - Mandelkow, E. AU - Mandelkow, E. -. M. PY - 2013 DA - 2013// TI - Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors JO - Neurobiol Aging VL - 34 UR - https://doi.org/10.1016/j.neurobiolaging.2012.10.024 DO - 10.1016/j.neurobiolaging.2012.10.024 ID - Messing2013 ER - TY - JOUR AU - Golovyashkina, N. AU - Penazzi, L. AU - Ballatore, C. AU - Smith, A. B. AU - Bakota, L. AU - Brandt, R. PY - 2015 DA - 2015// TI - Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes JO - Mol Neurodegener VL - 10 UR - https://doi.org/10.1186/s13024-015-0049-0 DO - 10.1186/s13024-015-0049-0 ID - Golovyashkina2015 ER - TY - JOUR AU - Tackenberg, C. AU - Grinschgl, S. AU - Trutzel, A. AU - Santuccione, A. C. AU - Frey, M. C. AU - Konietzko, U. PY - 2013 DA - 2013// TI - NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss JO - Cell Death Dis VL - 4 UR - https://doi.org/10.1038/cddis.2013.129 DO - 10.1038/cddis.2013.129 ID - Tackenberg2013 ER - TY - JOUR AU - Gu, J. AU - Congdon, E. E. AU - Sigurdsson, E. M. PY - 2013 DA - 2013// TI - Two novel tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce tau protein pathology JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.494922 DO - 10.1074/jbc.M113.494922 ID - Gu2013 ER - TY - JOUR AU - Congdon, E. E. AU - Gu, J. AU - Sait, H. B. R. AU - Sigurdsson, E. M. PY - 2013 DA - 2013// TI - Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.491001 DO - 10.1074/jbc.M113.491001 ID - Congdon2013 ER - TY - JOUR AU - Croft, C. L. AU - Moore, B. D. AU - Ran, Y. AU - Chakrabarty, P. AU - Levites, Y. AU - Golde, T. E. PY - 2018 DA - 2018// TI - Novel monoclonal antibodies targeting the microtubule-binding domain of human tau JO - PloS ONE VL - 13 UR - https://doi.org/10.1371/journal.pone.0195211 DO - 10.1371/journal.pone.0195211 ID - Croft2018 ER - TY - JOUR AU - Martin, L. AU - Latypova, X. AU - Wilson, C. M. AU - Magnaudeix, A. AU - Perrin, M. -. L. AU - Yardin, C. PY - 2013 DA - 2013// TI - Tau protein kinases: involvement in Alzheimer's disease JO - Ageing Res Rev VL - 12 UR - https://doi.org/10.1016/j.arr.2012.06.003 DO - 10.1016/j.arr.2012.06.003 ID - Martin2013 ER - TY - JOUR AU - Johansson, S. AU - Jämsä, A. AU - Vasänge, M. AU - Winblad, B. AU - Luthman, J. AU - Cowburn, R. F. PY - 2006 DA - 2006// TI - Increased tau phosphorylation at the Ser396 epitope after amyloid beta-exposure in organotypic cultures JO - Neuroreport VL - 17 UR - https://doi.org/10.1097/01.wnr.0000221844.35502.29 DO - 10.1097/01.wnr.0000221844.35502.29 ID - Johansson2006 ER - TY - JOUR AU - Nassif, M. AU - Hoppe, J. AU - Santin, K. AU - Frozza, R. AU - Zamin, L. L. AU - Simão, F. PY - 2007 DA - 2007// TI - β-Amyloid peptide toxicity in organotypic hippocampal slice culture involves Akt/PKB, GSK-3β, and PTEN JO - Neurochem Int VL - 50 UR - https://doi.org/10.1016/j.neuint.2006.08.008 DO - 10.1016/j.neuint.2006.08.008 ID - Nassif2007 ER - TY - JOUR AU - Chong, Y. H. AU - Shin, Y. J. AU - Lee, E. O. AU - Kayed, R. AU - Glabe, C. G. AU - Tenner, A. J. PY - 2006 DA - 2006// TI - ERK1/2 activation mediates Aβ oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M601016200 DO - 10.1074/jbc.M601016200 ID - Chong2006 ER - TY - JOUR AU - Rohn, T. T. PY - 2010 DA - 2010// TI - The role of caspases in Alzheimer’s disease; potential novel therapeutic opportunities JO - Apoptosis VL - 15 UR - https://doi.org/10.1007/s10495-010-0463-2 DO - 10.1007/s10495-010-0463-2 ID - Rohn2010 ER - TY - JOUR AU - Bruce, A. J. AU - Malfroy, B. AU - Baudry, M. PY - 1996 DA - 1996// TI - Beta-amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger JO - Proc Natl Acad Sci U S A VL - 93 UR - https://doi.org/10.1073/pnas.93.6.2312 DO - 10.1073/pnas.93.6.2312 ID - Bruce1996 ER - TY - JOUR AU - Phillips, E. C. AU - Croft, C. L. AU - Kurbatskaya, K. AU - O’Neill, M. J. AU - Hutton, M. L. AU - Hanger, D. P. PY - 2014 DA - 2014// TI - Astrocytes and neuroinflammation in Alzheimer's disease JO - Biochem Soc Trans VL - 42 UR - https://doi.org/10.1042/BST20140155 DO - 10.1042/BST20140155 ID - Phillips2014 ER - TY - JOUR AU - Tejera, D. AU - Heneka, M. T. PY - 2016 DA - 2016// TI - Microglia in Alzheimer's disease: the good, the bad and the ugly JO - Curr Alzheimers Res VL - 13 UR - https://doi.org/10.2174/1567205013666151116125012 DO - 10.2174/1567205013666151116125012 ID - Tejera2016 ER - TY - JOUR AU - Golde, T. E. PY - 2019 DA - 2019// TI - Harnessing immunoproteostasis to treat neurodegenerative disorders JO - Neuron VL - 101 UR - https://doi.org/10.1016/j.neuron.2019.02.027 DO - 10.1016/j.neuron.2019.02.027 ID - Golde2019 ER - TY - JOUR AU - Harris-White, M. E. AU - Balverde, Z. AU - Lim, G. P. AU - Kim, P. AU - Miller, S. A. AU - Hammer, H. PY - 2004 DA - 2004// TI - Role of LRP in TGFβ2-mediated neuronal uptake of Aβ and effects on memory JO - J Neurosci Res VL - 77 UR - https://doi.org/10.1002/jnr.20149 DO - 10.1002/jnr.20149 ID - Harris-White2004 ER - TY - JOUR AU - Marksteiner, J. AU - Humpel, C. PY - 2008 DA - 2008// TI - Beta-amyloid expression, release and extracellular deposition in aged rat brain slices JO - Mol Psychiatry VL - 13 UR - https://doi.org/10.1038/sj.mp.4002072 DO - 10.1038/sj.mp.4002072 ID - Marksteiner2008 ER - TY - JOUR AU - Fan, R. AU - Tenner, A. J. PY - 2004 DA - 2004// TI - Complement C1q expression induced by Aβ in rat hippocampal organotypic slice cultures JO - Exp Neurol VL - 185 UR - https://doi.org/10.1016/j.expneurol.2003.09.023 DO - 10.1016/j.expneurol.2003.09.023 ID - Fan2004 ER - TY - JOUR AU - Mazaheri, F. AU - Snaidero, N. AU - Kleinberger, G. AU - Madore, C. AU - Daria, A. AU - Werner, G. PY - 2017 DA - 2017// TI - TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury JO - EMBO Rep VL - 18 UR - https://doi.org/10.15252/embr.201743922 DO - 10.15252/embr.201743922 ID - Mazaheri2017 ER - TY - JOUR AU - Hochstrasser, T. AU - Hohsfield, L. A. AU - Sperner-Unterweger, B. AU - Humpel, C. PY - 2013 DA - 2013// TI - β-Amyloid induced effects on cholinergic, serotonergic, and dopaminergic neurons is differentially counteracted by anti-inflammatory drugs JO - J Neurosci Res VL - 91 ID - Hochstrasser2013 ER - TY - JOUR AU - Xu, K. AU - Malouf, A. T. AU - Messing, A. AU - Silver, J. PY - 1999 DA - 1999// TI - Glial fibrillary acidic protein is necessary for mature astrocytes to react to β-amyloid JO - Glia VL - 25 UR - https://doi.org/3.0.CO;2-7 DO - 3.0.CO;2-7 ID - Xu1999 ER - TY - JOUR AU - Kniewallner, K. M. AU - Grimm, N. AU - Humpel, C. PY - 2014 DA - 2014// TI - Platelet-derived nerve growth factor supports the survival of cholinergic neurons in organotypic rat brain slices JO - Neurosci Lett VL - 574 UR - https://doi.org/10.1016/j.neulet.2014.05.033 DO - 10.1016/j.neulet.2014.05.033 ID - Kniewallner2014 ER - TY - JOUR AU - Wong, Y. C. AU - Krainc, D. PY - 2017 DA - 2017// TI - [alpha]-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies JO - Nat Med VL - 23 UR - https://doi.org/10.1038/nm.4269 DO - 10.1038/nm.4269 ID - Wong2017 ER - TY - JOUR AU - Zach, S. AU - Bueler, H. AU - Hengerer, B. AU - Gillardon, F. PY - 2007 DA - 2007// TI - Predominant Neuritic pathology induced by viral overexpression of α-Synuclein in cell culture JO - Cell Mol Neurobiol VL - 27 UR - https://doi.org/10.1007/s10571-007-9141-5 DO - 10.1007/s10571-007-9141-5 ID - Zach2007 ER - TY - JOUR AU - Loria, F. AU - Vargas, J. Y. AU - Bousset, L. AU - Syan, S. AU - Salles, A. AU - Melki, R. PY - 2017 DA - 2017// TI - α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading JO - Acta Neuropathol VL - 134 UR - https://doi.org/10.1007/s00401-017-1746-2 DO - 10.1007/s00401-017-1746-2 ID - Loria2017 ER - TY - JOUR AU - McCaughey-Chapman, A. AU - Connor, B. PY - 2017 DA - 2017// TI - Rat brain sagittal organotypic slice cultures as an ex vivo dopamine cell loss system JO - J Neurosci Methods VL - 277 UR - https://doi.org/10.1016/j.jneumeth.2016.12.012 DO - 10.1016/j.jneumeth.2016.12.012 ID - McCaughey-Chapman2017 ER - TY - JOUR AU - Ayers, J. I. AU - Diamond, J. AU - Sari, A. AU - Fromholt, S. AU - Galaleldeen, A. AU - Ostrow, L. W. PY - 2016 DA - 2016// TI - Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS JO - Acta Neuropathol VL - 132 UR - https://doi.org/10.1007/s00401-016-1623-4 DO - 10.1007/s00401-016-1623-4 ID - Ayers2016 ER - TY - JOUR AU - Avossa, D. AU - Grandolfo, M. AU - Mazzarol, F. AU - Zatta, M. AU - Ballerini, L. PY - 2006 DA - 2006// TI - Early signs of motoneuron vulnerability in a disease model system: characterization of transverse slice cultures of spinal cord isolated from embryonic ALS mice JO - Neuroscience VL - 138 UR - https://doi.org/10.1016/j.neuroscience.2005.12.009 DO - 10.1016/j.neuroscience.2005.12.009 ID - Avossa2006 ER - TY - JOUR AU - Bi, F. AU - Huang, C. AU - Tong, J. AU - Qiu, G. AU - Huang, B. AU - Wu, Q. PY - 2013 DA - 2013// TI - Reactive astrocytes secrete lcn2 to promote neuron death JO - Proc Natl Acad Sci U S A VL - 110 UR - https://doi.org/10.1073/pnas.1218497110 DO - 10.1073/pnas.1218497110 ID - Bi2013 ER - TY - JOUR AU - Leggett, C. AU - McGehee, D. S. AU - Mastrianni, J. AU - Yang, W. AU - Bai, T. AU - Brorson, J. R. PY - 2012 DA - 2012// TI - Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices JO - J Neurol Sci VL - 317 UR - https://doi.org/10.1016/j.jns.2012.02.027 DO - 10.1016/j.jns.2012.02.027 ID - Leggett2012 ER - TY - JOUR AU - Reinhart, P. H. AU - Kaltenbach, L. S. AU - Essrich, C. AU - Dunn, D. E. AU - Eudailey, J. A. AU - DeMarco, C. T. PY - 2011 DA - 2011// TI - Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay JO - Neurobiol Dis VL - 43 UR - https://doi.org/10.1016/j.nbd.2011.03.017 DO - 10.1016/j.nbd.2011.03.017 ID - Reinhart2011 ER - TY - JOUR AU - Strang, K. e. v. i. n. H. AU - Croft, C. a. r. a. L. AU - Sorrentino, Z. a. c. h. a. r. y. A. AU - Chakrabarty, P. a. r. a. m. i. t. a. AU - Golde, T. o. d. d. E. AU - Giasson, B. e. n. o. i. t. I. PY - 2017 DA - 2017// TI - Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies JO - Journal of Biological Chemistry VL - 293 UR - https://doi.org/10.1074/jbc.M117.815357 DO - 10.1074/jbc.M117.815357 ID - Strang2017 ER - TY - JOUR AU - Sims, R. AU - Lee, S. J. AU - Naj, A. C. AU - Bellenguez, C. AU - Badarinarayan, N. AU - Jakobsdottir, J. PY - 2017 DA - 2017// TI - Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease JO - Nat Genet VL - 49 UR - https://doi.org/10.1038/ng.3916 DO - 10.1038/ng.3916 ID - Sims2017 ER - TY - JOUR AU - Kim, E. AU - Koo, T. AU - Park, S. W. AU - Kim, D. AU - Kim, K. AU - Cho, H. -. Y. PY - 2017 DA - 2017// TI - In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni JO - Nat Commun VL - 8 UR - https://doi.org/10.1038/ncomms14500 DO - 10.1038/ncomms14500 ID - Kim2017 ER - TY - JOUR AU - Xia, H. AU - Mao, Q. AU - Eliason, S. L. AU - Harper, S. Q. AU - Martins, I. H. AU - Orr, H. T. PY - 2004 DA - 2004// TI - RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia JO - Nat Med VL - 10 UR - https://doi.org/10.1038/nm1076 DO - 10.1038/nm1076 ID - Xia2004 ER - TY - JOUR AU - Piatkevich, K. D. AU - Jung, E. E. AU - Straub, C. AU - Linghu, C. AU - Park, D. AU - Suk, H. -. J. PY - 2018 DA - 2018// TI - A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters JO - Nat Chem Biol VL - 14 UR - https://doi.org/10.1038/s41589-018-0004-9 DO - 10.1038/s41589-018-0004-9 ID - Piatkevich2018 ER - TY - JOUR AU - Wu, J. AU - Abdelfattah, A. S. AU - Miraucourt, L. S. AU - Kutsarova, E. AU - Ruangkittisakul, A. AU - Zhou, H. PY - 2014 DA - 2014// TI - A long stokes shift red fluorescent Ca2+ indicator protein for two-photon and ratiometric imaging JO - Nat Commun VL - 5 UR - https://doi.org/10.1038/ncomms6262 DO - 10.1038/ncomms6262 ID - Wu2014 ER - TY - JOUR AU - Chen, T. -. W. AU - Wardill, T. J. AU - Sun, Y. AU - Pulver, S. R. AU - Renninger, S. L. AU - Baohan, A. PY - 2013 DA - 2013// TI - Ultrasensitive fluorescent proteins for imaging neuronal activity JO - Nature VL - 499 UR - https://doi.org/10.1038/nature12354 DO - 10.1038/nature12354 ID - Chen2013 ER - TY - JOUR AU - Krashes, M. J. AU - Koda, S. AU - Ye, C. AU - Rogan, S. C. AU - Adams, A. C. AU - Cusher, D. S. PY - 2011 DA - 2011// TI - Rapid, reversible activation of AgRP neurons drives feeding behavior in mice JO - J Clin Invest VL - 121 UR - https://doi.org/10.1172/JCI46229 DO - 10.1172/JCI46229 ID - Krashes2011 ER - TY - JOUR AU - Tervo, D. G. R. AU - Hwang, B. -. Y. AU - Viswanathan, S. AU - Gaj, T. AU - Lavzin, M. AU - Ritola, K. D. PY - 2016 DA - 2016// TI - A designer AAV variant permits efficient retrograde access to projection neurons JO - Neuron VL - 92 UR - https://doi.org/10.1016/j.neuron.2016.09.021 DO - 10.1016/j.neuron.2016.09.021 ID - Tervo2016 ER - TY - JOUR AU - Atasoy, D. AU - Aponte, Y. AU - Su, H. H. AU - Sternson, S. M. PY - 2008 DA - 2008// TI - A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and Long-range circuit mapping JO - J Neurosci VL - 28 UR - https://doi.org/10.1523/JNEUROSCI.1954-08.2008 DO - 10.1523/JNEUROSCI.1954-08.2008 ID - Atasoy2008 ER - TY - JOUR AU - Kaspar, B. K. AU - Vissel, B. AU - Bengoechea, T. AU - Crone, S. AU - Randolph-Moore, L. AU - Muller, R. PY - 2002 DA - 2002// TI - Adeno-associated virus effectively mediates conditional gene modification in the brain JO - Proc Natl Acad Sci U S A VL - 99 UR - https://doi.org/10.1073/pnas.042678699 DO - 10.1073/pnas.042678699 ID - Kaspar2002 ER - TY - JOUR AU - Varghese, K. AU - Das, M. AU - Bhargava, N. AU - Stancescu, M. AU - Molnar, P. AU - Kindy, M. S. PY - 2009 DA - 2009// TI - Regeneration and characterization of adult mouse hippocampal neurons in a defined in vitro system JO - J Neurosci Methods VL - 177 UR - https://doi.org/10.1016/j.jneumeth.2008.09.022 DO - 10.1016/j.jneumeth.2008.09.022 ID - Varghese2009 ER - TY - JOUR AU - Su, T. AU - Paradiso, B. AU - Long, Y. -. S. AU - Liao, W. -. P. AU - Simonato, M. PY - 2011 DA - 2011// TI - Evaluation of cell damage in organotypic hippocampal slice culture from adult mouse: a potential model system to study neuroprotection JO - Brain Res VL - 1385 UR - https://doi.org/10.1016/j.brainres.2011.01.115 DO - 10.1016/j.brainres.2011.01.115 ID - Su2011 ER - TY - JOUR AU - Wilhelmi, E. AU - Schoeder, U. H. AU - Benabdallah, A. AU - Sieg, F. AU - Breder, J. AU - Reymann, K. G. PY - 2002 DA - 2002// TI - Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time JO - Altern Lab Anim VL - 30 UR - https://doi.org/10.1177/026119290203000304 DO - 10.1177/026119290203000304 ID - Wilhelmi2002 ER - TY - JOUR AU - Osterloh, J. M. AU - Yang, J. AU - Rooney, T. M. AU - Fox, A. N. AU - Adalbert, R. AU - Powell, E. H. PY - 2012 DA - 2012// TI - dSarm/Sarm1 is required for activation of an injury-induced axon death pathway JO - Science VL - 337 UR - https://doi.org/10.1126/science.1223899 DO - 10.1126/science.1223899 ID - Osterloh2012 ER - TY - JOUR AU - Sundstrom, L. AU - Pringle, A. AU - Morrison, B. AU - Bradley, M. PY - 2005 DA - 2005// TI - Organotypic cultures as tools for functional screening in the CNS JO - Drug Discov Today VL - 10 UR - https://doi.org/10.1016/S1359-6446(05)03502-6 DO - 10.1016/S1359-6446(05)03502-6 ID - Sundstrom2005 ER -