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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Fig. 5

AICAR rescues basal respiration deficit induced by αsyn oligomers. a Mitochondrial OCR was assessed by Seahorse XFe96 Analyzer. The OCR is significantly reduced in cells overexpressing αsyn and AICAR significantly improves basal respiration (b). ATP production maximal respiration are trending towards rescue with AICAR (c, d) but AICAR had no effect on spare capacity (e). Error bars represent the mean ± SD. *p < 0.05, **p < 0.01. Note: #p is p value obtained with student t-test as one-way ANOVA analysis did not quite reach significance of p < 0.05

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