Fig. 8
From: Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway
Cartoon representing of αsyn-induced effect on SIRT3 and mitochondrial dysfunction. Consequences of decreased SIRT3 include decreased AMPK-CREB signaling, impairment in mitochondrial bioenergetics and dynamics, and increased acetylation of SIRT3 substrates such as SOD2 all of which contribute to increased ROS production and neurodegeneration. Question mark indicates pathway not supported by data in this manuscript