Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Table 1 Human brain samples

Case	Pathology Dx	Thal	Braak	Clinical Dx	Age at Death	Sex
1	Normal		2	aMCI	70	Male
2	Normal		0	Normal	56	Female
3	Normal		0	Normal	57	Female
4	Normal	0	2	AD v DLB	69	Male
5	Normal	1	1	DA	64	Female
6	Normal	0	3	DLB v FTD	63	Male
7	Normal		0	Normal	61	Female
8	Normal	1	1	NAIM	60	Female
9	Normal	0	1	PSP/PLS	56	Female
10	Normal	0	1	TD	61	Male
1	DLBD	0	0	DLB	60	Male
2	DLBD	0	2	DLB	61	Male
3	DLBD	0	2	PDD	66	Male
4	DLBD	0	0	PDD	68	Female
5	DLBD	1	2	PSP	72	Female
6	DLBD	1	2	DLB (RBD)	70	Male
7	DLBD	1	2	PDD	56	Male
8	DLBD	1	2.5	PDD	62	Female
9	DLBD	0	2	PD-MCI	66	Male
10	DLBD	2	1	PDD v CBD	69	Female

Dx Diagnosis, AD Alzheimer’s diseases, aMCI Amnestic mild cognitive impairment, CBD Corticobasal degeneration, DA Dysautonomia, DLBD Diffuse lewy body disease, DLB Dementia with lewy bodies, FTD Frontotemporal dementia, NAIM Nonvasculitic autoimmune inflammatory meningoencephalitis, PD Parkinson’s disease, PDD Parkinson’s disease with dementia, PLS Primary lateral sclerosis, PSP Progressive supranuclear palsy, RBD REM sleep behavior disorder, TD Torsion dystonia

ISSN: 1750-1326