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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

Fig. 4

Pharmacological chaperone reduces tau phosphorylation in 3xTg mice. a Representative Western blots of total soluble tau (HT7), and phosphorylated tau at residues Ser396 (PHF13), Ser396/Ser404 (PHF1), Ser202/Thr205 (AT8), Thr231/Ser235 (AT180), and Thr181 (AT270) in brain cortex homogenates from 3xTg mice treated with TPT (3xTg/TPT) or control (3xTg). b Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel. Values represent mean ± standard error of the mean (*p < 0.05, n = 3). c Representative immuno-histochemical staining images for PHF13, PHF1, AT8, AT180 and AT270 positive areas in brain hippocampus sections of 3xTg mice treated with TPT or control (scale bar: 100 μm). d Quantification of the integrated optical density (IOD) for the immunoreactivity to the same antibody shown in panel C. Values represent mean ± standard error of the mean (*p < 0.05, n = 4). e Representative western blots of GSK3α, GSK3β, p-GSK-3α, p-GSK-3β, cdk5, p35, p25, and PP2A in brain cortex homogenates from 3xTg mice treated with TPT or control (Ctrl) (n = 4 per group)

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Molecular Neurodegeneration

ISSN: 1750-1326