Skip to main content

Table 1 Study population. Whole-brain left hemispheres were collected at 6 months of age from female mice

From: Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

Model

Genetic Construct

JAX Strain name

JAX Stock #

B6

none; control

C57BL/6 J

000664

APOEε4

Homozygous transgene of human APOEε4 allele with GFAP promoter

B6.Cg-Apoetm1Un Cdh18Tg(GFAP-APOE_i4)1Hol/J

004631

Apoe−/−

Homozygous gene knockout

B6.129P2-Apoetm1Unc/J

002052

Clu−/−

Homozygous gene knockout

B6.Cg-Clutm1Jakh/J

005642

Bin1+/−

Heterozygous gene knockout

B6.129S6-Bin1tm2Gcp/J

021145

Cd2ap+/−

Heterozygous gene knockout

B6.129X1-Cd2aptm1Shaw/J

008907

APP/PS1

Homozygous transgenic

B6.Cg-Tg (APPswe,PSEN1dE9) 85Dbo/Mmjax

MMRC stock # 34,832-JAX