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Table 2 Differentially expressed genes by strain. Number of differentially expressed genes identified in each mouse strain compared to control mice (B6)

From: Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

Mouse Model

Upregulated

Downregulated

APOEε4

57

63

Apoe−/−

154

65

Clu−/−

762

997

Bin1+/−

10

6

Cd2ap+/−

21

13

APP/PS1

67

183