From: Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
Mouse Model
Upregulated
Downregulated
APOEε4
57
63
Apoe−/−
154
65
Clu−/−
762
997
Bin1+/−
10
6
Cd2ap+/−
21
13
APP/PS1
67
183