Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

Table 5 Results of mixed-effects regression models predicting cognitive test performance from dietary cholesterol and egg intake

Cognitive tests	Dietary cholesterol2		Dietary cholesterol		Egg intake2		Egg intake
Cognitive tests	β	P value	β	P value	β	P value	β	P value
Model 1
MoCA	−0.00000142	0.023*	0.0020	0.001*	−0.0000197	0.331	0.0046	0.135
AVLT-IR	− 0.00000124	0.19	0.0018	0.052	−0.0000157	0.605	0.0030	0.508
AVLT-SR	−0.000000754	0.122	0.0006	0.223	−0.0000111	0.478	0.0003	0.895
AVLT-LR	−0.000000834	0.121	0.0006	0.28	−0.00000582	0.737	−0.0005	0.836
SDMT	− 0.00000713	0.001*	0.0066	0.003*	−0.0001176	0.097	0.0145	0.172
DSF	− 0.00000047	0.072	0.0005	0.048*	−0.000022	0.008*	0.0044	0.001*
LMT	−0.00000158	0.201	0.0023	0.064	−0.0000214	0.588	0.0073	0.225
Model 2
MoCA	−0.00000142	0.023*	0.0020	0.001*	−0.0000198	0.328	0.0046	0.133
AVLT-IR	− 0.00000124	0.19	0.0018	0.053	−0.000016	0.598	0.0031	0.504
AVLT-SR	−0.000000751	0.122	0.0006	0.231	− 0.0000113	0.469	0.0003	0.893
AVLT-LR	−0.000000831	0.122	0.0006	0.288	−0.00000602	0.728	−0.0005	0.836
SDMT	−0.0000071	0.001*	0.0066	0.003*	−0.0001177	0.096	0.0145	0.174
DSF	−0.000000475	0.069	0.0005	0.045*	−0.0000221	0.008*	0.0044	< 0.001*
LMT	−0.00000157	0.205	0.0023	0.067	−0.0000215	0.587	0.0072	0.229

Abbreviations: MoCA Montreal Cognitive Assessment, AVLT-IR auditory verbal learning test-immediate recall, AVLT-SR auditory verbal learning test-short recall, AVLT-LR auditory verbal learning test-long recall, SDMT symbol digit modalities test, DSF digit span forwards, LMT logical memory test
β: unstandardized regression coefficients were obtained from mixed-effects regression models
Model 1 was adjusted for sex, age, education years, BMI, smoking and drinking status, diabetes, hypertension and coronary artery disease history and per se use of lipid-lowering medication and intakes of energy, protein, carbohydrates, fat, SFA, PUFA, and MUFA
Model 2 was adjusted as for model 1 and for number of APOE ε4 alleles
∗P < 0.05

ISSN: 1750-1326