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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

Fig. 3

Contribution of GABAergic neurons to Aβ pathology in an APP knock-in mouse model. a Representative masks generated by IHC to quantify laminar plaque load in hippocampal sections from AppNL-G-F/NL-G-F; GAD2Cre (control; black bars) and AppNL-G-F/NL-G-F; GAD2Cre;Bace1flox/flox (Bace1cKO in GABAergic neurons; white bars). b-e Quantification of the Aβ plaque load in hippocampal subfields b and laminae of CA1 c, CA2/3 d, and dentate gyrus (DG) e as determined by IHC. Graphs show means ± SEM. (n = 8 mice; two-way ANOVA) f-g Quantification of Aβ42 measured by ELISA from TBS soluble f and insoluble g fractions of hippocampal brain homogenates. (n = 12 mice; student’s t-test) SO = stratum oriens; SP = stratum pyramidale; SR = stratum radiatum; SLM = stratum lacunosum-moleculare; MO = molecular layer; SG = stratum granulosum; H = hilus; DG = dentate gyrus. *P < 0.05, **P < 0.01

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