Fig. 8
From: α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment
Nilotinib treatment decreases astrocyte and microglia reactivity in the brain. Nilotinib (Nilo) or DMSO (vehicle) treated end-stage TgA53T (Tg) mice and aged-match littermate nTg were used to obtain brain tissue and immunostained using GFAP antibody (a, b) and Iba1 antibody (c, d). Tg-DMSO shows an increase of highly active and proliferated astrocytes compare to nTg control, whereas Nilo treatment shows a reduction of astrocytes and microglia reactivity and proliferation compare to vehicle (Tg-DMSO) treatment. a, c Stitched-image of nTg, Tg-DMSO and Tg-Nilo of sagittal brain. Scale bar, 500 μm. b, d Brainstem. Scale bar, 100 μm