Table 1 Main genes and cellular components/processes implicated in the pathogenesis of ALS and FTD
From: From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline
| RNA metabolism | TARDBP, FUS, hnRNPA1, hnRNPA2B1, MATR3, ATXN2, TAF15, SETX, EWSR1, ELP3, ANG |
| Protein trafficking and Proteostasis | C9ORF72, CHMP2B, FIG 4, TBK1, UBQLN2, SQSTM1, SIGMAR1, OPTN, VCP, ALS2, VAPB |
| DNA repair | EWSR1, FUS, SETX, TAF15, TARDBP |
| Mitochondria and Oxidative stress: | SOD1, CHCHD10, C19ORF12 |
| Immune response/Inflammation: | GRN, TREM2, TYROBP |
| Stress granule assembly | ATXN2, C9ORF72, MAPT |
| Glia and Neurons metabolism | GRN, SIGMAR1, SOD1, TREM2, TYROBP |
| Vacuolar transport | C9ORF72, CHMP2B, GRN, TMEM106B, VCP, OPTN, UNC13A |
| Axo-dendritic transport | KIF5A, MAPT, SPG11 |