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Table 1 Main genes and cellular components/processes implicated in the pathogenesis of ALS and FTD

From: From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline

RNA metabolism TARDBP, FUS, hnRNPA1, hnRNPA2B1, MATR3, ATXN2, TAF15, SETX, EWSR1, ELP3, ANG
Protein trafficking and Proteostasis C9ORF72, CHMP2B, FIG 4, TBK1, UBQLN2, SQSTM1, SIGMAR1, OPTN, VCP, ALS2, VAPB
DNA repair EWSR1, FUS, SETX, TAF15, TARDBP
Mitochondria and Oxidative stress: SOD1, CHCHD10, C19ORF12
Immune response/Inflammation: GRN, TREM2, TYROBP
Stress granule assembly ATXN2, C9ORF72, MAPT
Glia and Neurons metabolism GRN, SIGMAR1, SOD1, TREM2, TYROBP
Vacuolar transport C9ORF72, CHMP2B, GRN, TMEM106B, VCP, OPTN, UNC13A
Axo-dendritic transport KIF5A, MAPT, SPG11