Skip to main content

Table 1 Main genes and cellular components/processes implicated in the pathogenesis of ALS and FTD

From: From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline

RNA metabolism

TARDBP, FUS, hnRNPA1, hnRNPA2B1, MATR3, ATXN2, TAF15, SETX, EWSR1, ELP3, ANG

Protein trafficking and Proteostasis

C9ORF72, CHMP2B, FIG 4, TBK1, UBQLN2, SQSTM1, SIGMAR1, OPTN, VCP, ALS2, VAPB

DNA repair

EWSR1, FUS, SETX, TAF15, TARDBP

Mitochondria and Oxidative stress:

SOD1, CHCHD10, C19ORF12

Immune response/Inflammation:

GRN, TREM2, TYROBP

Stress granule assembly

ATXN2, C9ORF72, MAPT

Glia and Neurons metabolism

GRN, SIGMAR1, SOD1, TREM2, TYROBP

Vacuolar transport

C9ORF72, CHMP2B, GRN, TMEM106B, VCP, OPTN, UNC13A

Axo-dendritic transport

KIF5A, MAPT, SPG11