From: From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline
RNA metabolism | TARDBP, FUS, hnRNPA1, hnRNPA2B1, MATR3, ATXN2, TAF15, SETX, EWSR1, ELP3, ANG |
Protein trafficking and Proteostasis | C9ORF72, CHMP2B, FIG 4, TBK1, UBQLN2, SQSTM1, SIGMAR1, OPTN, VCP, ALS2, VAPB |
DNA repair | EWSR1, FUS, SETX, TAF15, TARDBP |
Mitochondria and Oxidative stress: | SOD1, CHCHD10, C19ORF12 |
Immune response/Inflammation: | GRN, TREM2, TYROBP |
Stress granule assembly | ATXN2, C9ORF72, MAPT |
Glia and Neurons metabolism | GRN, SIGMAR1, SOD1, TREM2, TYROBP |
Vacuolar transport | C9ORF72, CHMP2B, GRN, TMEM106B, VCP, OPTN, UNC13A |
Axo-dendritic transport | KIF5A, MAPT, SPG11 |