Table 3 Effect of the genetic modifiers of ALS and FTD
From: From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline
GRN | SORT1 | rs646776 C-minor allele => decreased GRN plasma expression | |
GRN | TMEM106B | rs1990622 C-minor allele => lower risk (older age at onset) | |
C9ORF72 | TMEM106B | rs1990622 C-minor allele => earlier onset | [96] |
rs3173615 G minor allele => Homozygosity protects from developing FTD but not from developing MND | [97] | ||
-- | TMEM106B | rs1990622 T-major allele => poorer cognitive performance in FTLD-TDP patients not in ALS patients | [98] |
-- | TMEM106B | rs1990622 C-minor allele => protective effect on cognitive aging |