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Table 3 Effect of the genetic modifiers of ALS and FTD

From: From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline

GRN SORT1 rs646776 C-minor allele => decreased GRN plasma expression [92, 93]
GRN TMEM106B rs1990622 C-minor allele => lower risk (older age at onset) [94, 95]
C9ORF72 TMEM106B rs1990622 C-minor allele => earlier onset [96]
rs3173615 G minor allele => Homozygosity protects from developing FTD but not from developing MND [97]
-- TMEM106B rs1990622 T-major allele => poorer cognitive performance in FTLD-TDP patients not in ALS patients [98]
-- TMEM106B rs1990622 C-minor allele => protective effect on cognitive aging [99,100,101]