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Table 1 mtDNA changes in AD

From: Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

Mutation type Affected mtDNA region Analysis Method Changes in AD Reference
mtDNA Δ4977 I, III and V PCR Increased Corral-Debrinski et al. [80]
mtDNA Δ4977 I, III and V PCR No changes Blanchard et al. [79]
mtDNA Δ4977 I, III and V In situ hybridization Increased Hirai et al. [87]
mtDNA Δ4977 I, III and V PCR No changes Bender et al. [90]
mtDNA Δ4977 I, III and V PCR Increased Krishnan et al. [88]
mtDNA Δ4977 I, III and V Realtime PCR No changes Strobel et al. [89]
DNA Rearrangement Mitochondrial genome Next generation sequencing Increased Chen et al. [81]
Point mutation D-loop region PCR/Sanger sequencing Increased Coskun et al. [82]
Point mutation Mitochondrial genome Random mutation capture No changes Soltys et al. [83]
Point mutation Mitochondrial genome PCR-cloning-sequencing Increased Lin et al. [84]
Point mutation Mitochondrial genome Next generation sequencing Increased Hoekstra et al. [91]
DNA methylation D-loop region TaqMan PCR Increased Blanch et al. [96]
DNA methylation D-loop region Realtime PCR Decreased Stoccoro et al. [97]