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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer’s disease

Fig. 3

Moesin is expressed by microglia and endothelial cells in mouse brain. a Representative immunofluorescence images of Cx3cr1CreER-YFP-WT (N = 4) and Cx3cr1CreER-YFP-5xFAD (N = 6) mouse cortex stained for microglia (GFP) and Msn. Arrow indicates microglia immunopositive for GFP and Msn. Asterisk indicates cells immunopositive for Msn only. b Representative immunofluorescence images of Cx3cr1CreER-YFP-5xFAD (N = 6) mouse cortex stained for amyloid-beta (Aβ), microglia (GFP), and Msn. Arrow indicates Aβ plaque as well as microglia immunopositive for GFP and Msn. c Representative immunofluorescence images of WT (N = 3) and 5xFAD (N = 4) mouse cortex stained for endothelial cells (CD31) and Msn. Arrow indicates endothelial cells immunopositive for CD31 and Msn. Asterisk indicates cells immunopostive for Msn only. d Representative immunofluorescence images of WT (N = 3) and 5xFAD (N = 4) mouse cortex stained for astrocytes (GFAP) and Msn. Arrow indicates cells immunopositive for Msn only. Asterisk indicates astroctyes immunopostive for GFAP only. Scale bar = 30 μm

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