Fig. 1
From: Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes
Genetic knockout of IL-6 in the R6/2 HD model. a. Schematic of mouse breeding and genotypes used for the study. All R6/2 (exon1 mHTT) HD model mice in this study were hemizygous (hemi) carriers of the R6/2 transgene. F1 heterozygous mice were used for breeding to obtain F2 mice used for behavioral and biochemical analyses. b. Timeline of behavioral studies in the IL-6_KO x WT and R6/2 animals. Due to advancement of HD model phenotypes, animals were harvested at 10 weeks of age after open field testing and fresh frozen striatal tissue was dissected and used for snRNA-seq analysis