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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes

Fig. 3

snRNA-seq from R6/2 IL-6 knockout mice reveals cell-type specific gene expression changes in striatal cell types induced by IL-6 deficiency. a. ACTIONet plot of striatal cell types detected by snRNA-seq. b. The top five most downregulated and upregulated non-mitochondrial, protein-coding genes by log2-fold change in the most abundant striatal cell types induced by IL-6 deficiency in WT_KO (left panel) and R6/2_KO HD model mice (right panel)

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Molecular Neurodegeneration

ISSN: 1750-1326