Fig. 4
From: Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes
Gene pathways and predicted transcriptional regulators affected by IL-6 knockout. a. Enriched KEGG pathways of genes downregulated and upregulated in dSPNs and iSPNs upon IL-6 deficiency in WT_KO (top panel) and R6/2_KO HD model mice (bottom panel), represented with Fisher’s exact test –log10-adjusted p-value. b. Predicted transcriptional regulators, by ChEA analysis, of genes that were downregulated and upregulated in dSPNs and iSPNs upon IL-6 deficiency in WT_KO (top panel) and R6/2_KO HD model mice (bottom panel), represented with Fisher’s exact test –log10-adjusted p-value