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Fig. 9 | Molecular Neurodegeneration

Fig. 9

From: Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice

Fig. 9

Summary of the Ca2+ signaling alterations in APOE4 astrocytes. a) Ca2+ signaling pathway of APOE3 (a) and APOE4 (b) astrocytes in the presence (left) or absence (right) of extracellular lipids. The name of  channels and receptors that increase cytosolic Ca2+ are in blue rectangles, whereas pathways decreasing cytosolic Ca2+ are in green rectangles. The size of the arrows indicates if the process is increased with respect to APOE3 astrocytes in the presence of extracellular lipids. Plasma-membrane lipids and lipoproteins are shown in different colors in APOE3 and APOE4 astrocytes to reflect their different lipid composition. Organelle and plasmatic membrane graphs were obtained from Smart Servier Medical Art (https://smart.servier.com/)

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