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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease

Fig. 4

Expression levels of reported and novel AD CSF biomarker candidates in cortex and CSF proteomes. a Dot plots overlaid onto boxplots showing expression levels of biomarker candidates that are consistently detected in at least two independent MS-based AD CSF proteome studies in the cortex and CSF proteomes. The p values of the DE analyses between AD and healthy control are displayed on the top of the plots. DE analyses were carried out through the LIMMA R package. X-axis shows sample groups, y-axis indicates Log2 transformed TMT intensity. Boxplot center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; points, expression levels of each individual samples. b Dot plots overlaid onto boxplots showing expression levels of novel biomarker candidates detected in our ultra-deep proteome in cortex and CSF datasets. The p values of the DE analyses between AD and healthy control are displayed on the top of the plots. DE analyses were carried out through the LIMMA R package. X-axis shows sample groups, y-axis indicates Log2 transformed TMT intensity. Boxplot center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; points, expression levels of each individual samples

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