Fig. 7

Integrating the protein rankings in individual datasets though order statistics prioritizes top AD signatures. a Workflow for tiered integration of individual proteome ranking by order statistics. Rank of each individual dataset was integrated by discovery or reference cohorts separately first, and was then combined into cortex, CSF, or serum ranking. Lastly, the three ranks were integrated into a final integrative ranking. b Top protein signatures of Alzheimer’s disease prioritized through the integrated ranking. Heatmap shows the ranking of top AD signature proteins with a final integrated ranking p value < 0.001 in each of the ten datasets. Protein ranks are labeled on the right side of the heatmap. The rankings of proteins are shown by boxes of two-color gradients, with missing values indicated by grey boxes. c Mitochondrial function is the most significantly enriched pathway in the integrated ranking. Pathways are enriched by GSEA and further categorized into four groups. The barcode plots represent the positions of proteins in the sorted integrated ranking