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Table 1 Summary of Human and Mouse Proteome Datasets for Biomarker Analysis

From: Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease

Tissue Type Dataset Total Case AD MCI Control Proteins Quantified Reference
Human Cortex i 48 19 7 22 12,578 This study and cohort 1 in Bai B, et al. Neuron. 2020
Human Cortex ii 62 23 0 39 13,702 Cohort 2 in Bai B, et al. Neuron. 2020
Human Cortex iii 40 10 20 10 8817 Cortex cohort 1 in Higginbotham L, bioRxiv. 2019
Human Cortex iv 27 9 8 10 11,244 Cortex cohort 2 in Higginbotham L, bioRxiv. 2019
Human CSF v 20 11 0 9 5941 This study and Bai B, et al. Neuron. 2020
Human CSF vi 40 20 0 20 2875 CSF cohort 1 in Higginbotham L, bioRxiv. 2019
Human CSF vii 96 33 31 32 792 CSF cohort 2 in Higginbotham L, bioRxiv. 2019
Human CSF viii 10 5 0 5 2321 Sathe G, et al. Proteomics Clinical Applications. 2019
a Mouse CSF ix 11 6 0 5 1058 This study
Human Serum x 11 6 0 5 4826 Dey KK, et al. Clinical Proteomics. 2019
Summary 10 365 142 66 157 17,541  
  1. aNote: AD cases are 5 x FAD mice, control cases are age matched healthy mice
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