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Table 1 Summary of Human and Mouse Proteome Datasets for Biomarker Analysis

From: Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease

Tissue Type

Dataset

Total Case

AD

MCI

Control

Proteins Quantified

Reference

Human Cortex

i

48

19

7

22

12,578

This study and cohort 1 in Bai B, et al. Neuron. 2020

Human Cortex

ii

62

23

0

39

13,702

Cohort 2 in Bai B, et al. Neuron. 2020

Human Cortex

iii

40

10

20

10

8817

Cortex cohort 1 in Higginbotham L, bioRxiv. 2019

Human Cortex

iv

27

9

8

10

11,244

Cortex cohort 2 in Higginbotham L, bioRxiv. 2019

Human CSF

v

20

11

0

9

5941

This study and Bai B, et al. Neuron. 2020

Human CSF

vi

40

20

0

20

2875

CSF cohort 1 in Higginbotham L, bioRxiv. 2019

Human CSF

vii

96

33

31

32

792

CSF cohort 2 in Higginbotham L, bioRxiv. 2019

Human CSF

viii

10

5

0

5

2321

Sathe G, et al. Proteomics Clinical Applications. 2019

a Mouse CSF

ix

11

6

0

5

1058

This study

Human Serum

x

11

6

0

5

4826

Dey KK, et al. Clinical Proteomics. 2019

Summary

10

365

142

66

157

17,541

 
  1. aNote: AD cases are 5 x FAD mice, control cases are age matched healthy mice