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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

Fig. 3

BIN1 expression in microglia. a RNA expression of BIN1 isoforms expressed in human primary microglia isolated from human fresh autopsy tissue. Two different batches of human microglia with n = 8 subjects on the left and n = 13 subjects on the right showed comparable results. b-e Co-immunostaining in post-mortem human brain tissue (n = 3) with antibodies recognizing specific BIN1 exons in red (exons 7, 11, 13 or 17, which recognizes isoforms 1–9) and the microglial marker CD45 in green. Cells which express both sets of markers have a yellowish color. f Analysis of gene expression level of BIN1 (all isoforms, including isoforms 10 and 12) in monocytes and MDMi (n = 19). No difference of gene expression level reported for CD14, a marker of myeloid cells, between two cellular models. Relative gene expression is reported on the Y-axis

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Molecular Neurodegeneration

ISSN: 1750-1326