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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

Fig. 5

Association of BIN1 peptides with AD pathology. a Association between the abundance of BIN1 peptides and amyloid (left) or tangles (right) after adjusting for the other form of AD-related pathology. b Effect size of BIN1 peptides localized in exon 7 in relation to the abundance of tangles: there is an inverse relationship between the two factors. c Graph illustrating the results of our mediation analyses which suggest that BIN1 exon 7 peptides (i.e LQAHLVAQTNLLR) play a role in the accumulation of tangles and do not have an independent effect on cognitive decline. d Association of BIN1 peptides with APOEε4. The threshold of significance is reported on the Y axis and is denoted by the horizontal dashed line as the -log of the FDR value (FDR < 0.05)

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