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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

Fig. 6

Association between BIN1 isoforms and AD pathology in brain post-mortem tissue. a Co-immunostaining using an antibody recognizing specifically BIN1 exon 7 in red and a neuronal marker (NeuN) in green in human post-mortem brain tissues for n = 3 AD and n = 4 non-AD subjects. The number of neurons expressing exon 7 and the total number of neurons have been quantified using the software CellProfiler and CellProfiler Analyst. b Co-immunostaining in human post-mortem brain tissues using an antibody recognizing specifically BIN1 exon 7 in red and an astrocyte marker (ALDH1L1) in green for n = 9 AD and n = 9 non-AD subjects. Cells which express both sets of markers have a yellowish color. The number of astrocytes expressing exon 7 and the total number of astrocytes have been quantified using the software CellProfiler and CellProfiler Analyst. A t-test has been used for statistical analysis using Prism software. The thresholds of significance are p < 0.05* and p < 0.005**

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