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Table 1 Demographics and CSF characteristics of DLB patients and controls

From: Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach

  Cohort 1 (n = 40) Cohort 2 (n = 30) Cohort 3B (n = 76)#
DLB (n = 20) Controls (n = 20) DLB (n = 17) Controls (n = 13) DLB (n = 48) Controls (n = 28)
Age, yr
range [min-max]
65.3 ± 5.8
[54.1–76.5]
65.1 ± 5.4
[53.9–74.0]
66.9 ± 7.5
[53.9–74.0]
65.6 ± 8.5
[52.4–76.7]
67.8 ± 6.3*
[54.1–78.4]
64.1 ± 5.8
[53.9–74.0]
Male sex 17 (85%) 17 (85%) 13 (76%) 9 (69%) 42 (88%) 24 (86%)
Symptom duration, yr 3 [2–4] N/A 2 [2–4] N/A 2 [1–4] N/A
MMSE 23 [21–26]*** 28 [27–29] 26 [21–28]* 29 [28–30] 23 [21–26]*** 28 [27–30]
CSF AD biomarkers
1–42, (pg/ml)
Abnormal
846 [637–1011]
0 (0%)
820 [691–1039]
0 (0%)
611 [478–942]*
8 (47%)
959 [932–1054]
0 (0%)
660 [536–871]**
13 (27%)
856 [691–1027]
0 (0%)
total tau, (pg/ml)
Abnormal
238 [200–286]
0 (0%)
209 [167–266]
0 (0%)
317 [268–599]**
8 (47%)
226 [194–253]
0 (0%)
299 [224–370]***
11 (23%)
190 [156–257]
0 (0%)
p-tau, (pg/ml)
Abnormal
37 [29–47]
0 (0%)
42 [31–47]
0 (0%)
46 [41–71]
7 (41%)
41 [37–49]
0 (0%)
47 [34–61]*
18 (37%)
38 [28–46]
0 (0%)
APOE ε4 carrier 9 (45%) 8 (40%) 10 (71%)** 2 (17%) 25 (55%) 10 (38%)
  1. Data are presented as mean ± SD for normally distributed continuous variables, as median [first quartile – third quartile] for non-normally distributed continuous variables or as n (%) for categorical variables
  2. CSF cutoff values were set on Aß1–42 < 550 pg/ml, total tau > 375 pg/ml, p-tau > 52 pg/ml [17]
  3. Differences between DLB patients and controls were assessed with Student’s t-test, Wilcoxon signed-rank test or Fisher’s Exact Test.* p < 0.05, ** p < 0.01, *** p < 0.001
  4. #NPTX2 ELISA: n = 76 (DLB: n = 48, Controls: n = 28); VGF ELISA: n = 66 (DLB: n = 44, Controls: n = 22); VGF SRM: n = 65 (DLB: n = 44, Controls: n = 21)
  5. Abbreviations: 1–42 ß-Amyloid 1–42, AD Alzheimer’s disease, APOE Apoliproprotein E, CSF Cerebrospinal fluid, DLB Dementia with Lewy bodies, MMSE Mini mental State examination (score range 0–30), N/A Not applicable, p-tau Tau phosphorylated at threonine 181