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Table 2 Overlapping differentially expressed proteins between cohort 1 and 2

From: Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach

Uniprot ID

Gene name

Protein name

Fold change in discovery cohort

Fold change in validation cohort

CSF Peer literature (see Suppl. Table 3for references)

O15240

VGF

Neurosecretory protein VGF

−1.78

−1.41

↓ in AD, FTD

and ALS

↑ in schizophrenia

P13521

SCG2

Secretogranin-2

−1.36

−1.30

↓ in MS

↓ in AD

P47972

NPTX2

Neuronal pentraxin-2

−1.55

−1.50

↓ in AD

O95502

NPTXR

Neuronal Pentraxin Receptor

−1.31

−1.32

↓ in AD

P01213

PDYN

Proenkephalin-B

−4.33

−8.78

↓ in AD

Q9UHG2

PCSK1N

ProSAAS

−1.22

−1.21

↓ in AD

↓ in FTD

  1. Table lists the six CSF biomarker candidates for DLB. A positive fold change indicates that the protein is upregulated in the DLB group in contrast to the control group. A negative fold change indicates the protein is downregulated in the DLB group compared to the control group
  2. Abbreviations: AD Alzheimer’s disease, ALS Amyotrophic lateral sclerosis, DLB Dementia with Lewy bodies, FTD Frontotemporal dementia, MS Multiple sclerosis, NPTX2 Neuronal pentraxin 2, NPTXR Neuronal pentraxin receptor, PCSK1N, ProSAAS, PDYN Proenkephalin-B, SCG2 Scretogranin-2, VGF Neurosecretory protein VGF