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Table 2 Overlapping differentially expressed proteins between cohort 1 and 2

From: Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach

Uniprot ID Gene name Protein name Fold change in discovery cohort Fold change in validation cohort CSF Peer literature (see Suppl. Table 3for references)
O15240 VGF Neurosecretory protein VGF −1.78 −1.41 ↓ in AD, FTD
and ALS
↑ in schizophrenia
P13521 SCG2 Secretogranin-2 −1.36 −1.30 ↓ in MS
↓ in AD
P47972 NPTX2 Neuronal pentraxin-2 −1.55 −1.50 ↓ in AD
O95502 NPTXR Neuronal Pentraxin Receptor −1.31 −1.32 ↓ in AD
P01213 PDYN Proenkephalin-B −4.33 −8.78 ↓ in AD
Q9UHG2 PCSK1N ProSAAS −1.22 −1.21 ↓ in AD
↓ in FTD
  1. Table lists the six CSF biomarker candidates for DLB. A positive fold change indicates that the protein is upregulated in the DLB group in contrast to the control group. A negative fold change indicates the protein is downregulated in the DLB group compared to the control group
  2. Abbreviations: AD Alzheimer’s disease, ALS Amyotrophic lateral sclerosis, DLB Dementia with Lewy bodies, FTD Frontotemporal dementia, MS Multiple sclerosis, NPTX2 Neuronal pentraxin 2, NPTXR Neuronal pentraxin receptor, PCSK1N, ProSAAS, PDYN Proenkephalin-B, SCG2 Scretogranin-2, VGF Neurosecretory protein VGF