Fig. 4
From: Deciphering cellular transcriptional alterations in Alzheimer’s disease brains
Comparison of CI-DEGs from computational deconvolution with CI-DEGs from snRNAseq on DLPFC dataset. a. Upper panel: number of overlapping genes (y-axis) between the top N (x-axis) up-regulated genes in snDLPFC and top N up-regulated genes from bulk-DLPFC deconvoluted with PSEA, WLC and CellCODE, respectively. Lower panel: number of overlapping genes (y-axis) between the top N (x-axis) down-regulated genes in snDLPFC and top N down-regulated genes from deconvoluted bulk-DLPFC. b. Venn diagram of CI-DEGs from computational deconvolution methods and those from snRNAseq. Overlap is evaluated for both bulk-DLPFC and snDLPFC CI-DEGs detected at nominal p value ≤0.05