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Table 1 Mouse Models Analyzed

From: Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1

Mouse Lines I5 J20 KI
Genotype hAPP-I5 hAPP-J20 AppNL-G-F
Genetic Modification hAPP transgene hAPP transgene App knock-in
APP mutationsa None Swedish (KM670/671NL)
Indiana (V717F)
Humanized Aβ sequence
Swedish (KM670/671NL)
Arctic (E693G)
Beyreuther/Iberian (I716F)
APP Isoforms Expressed hAPP770
hAPP751
hAPP695
hAPP770
hAPP751
hAPP695
Unknown
(presumably mostly APP695)
Promoter Human PDGF-β Human PDGF-β Mouse App
Genetic Background C57BL/6 J C57BL/6 J C57BL/6 J
Original Reference Mucke et al., 2000 Mucke et al., 2000 Saito et al., 2014
  1. a with reference to APP770; N/A not applicable
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