Mouse Lines | I5 | J20 | KI |
---|---|---|---|
Genotype | hAPP-I5 | hAPP-J20 | AppNL-G-F |
Genetic Modification | hAPP transgene | hAPP transgene | App knock-in |
APP mutationsa | None | Swedish (KM670/671NL) Indiana (V717F) | Humanized Aβ sequence Swedish (KM670/671NL) Arctic (E693G) Beyreuther/Iberian (I716F) |
APP Isoforms Expressed | hAPP770 hAPP751 hAPP695 | hAPP770 hAPP751 hAPP695 | Unknown (presumably mostly APP695) |
Promoter | Human PDGF-β | Human PDGF-β | Mouse App |
Genetic Background | C57BL/6 J | C57BL/6 J | C57BL/6 J |
Original Reference | Mucke et al., 2000 | Mucke et al., 2000 | Saito et al., 2014 |