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Table 1 Mouse Models Analyzed

From: Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1

Mouse Lines

I5

J20

KI

Genotype

hAPP-I5

hAPP-J20

AppNL-G-F

Genetic Modification

hAPP transgene

hAPP transgene

App knock-in

APP mutationsa

None

Swedish (KM670/671NL)

Indiana (V717F)

Humanized Aβ sequence

Swedish (KM670/671NL)

Arctic (E693G)

Beyreuther/Iberian (I716F)

APP Isoforms Expressed

hAPP770

hAPP751

hAPP695

hAPP770

hAPP751

hAPP695

Unknown

(presumably mostly APP695)

Promoter

Human PDGF-β

Human PDGF-β

Mouse App

Genetic Background

C57BL/6 J

C57BL/6 J

C57BL/6 J

Original Reference

Mucke et al., 2000

Mucke et al., 2000

Saito et al., 2014

  1. a with reference to APP770; N/A not applicable