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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

Fig. 5

APOE isoform-specific effect on gene expression. RNA-seq data shown in Fig. 4 were analyzed using edgeR to identify differentially expressed genes between APOE isoforms. Scatterplots depict differentially expressed genes between APP/E3 vs APP/E4 (a), APP/E3/Trem2ko vs APP/E4/Trem2ko (b) E3 vs E4 (c), and E3/Trem2ko vs E4/Trem2ko mice (d). Shown are genes at p < 0.05 cutoff. Heatmaps and line patterning graphs of DAM and homeostatic microglia genes that are upregulated in either APOE4 (e-f) or in APOE3 mice (g-h) mice in a Trem2 and APOE-isoform dependent manner. Genes of interest are marked with colored circles and shown as line patterning

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