Fig. 2
From: Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer’s disease
Multimodal imaging signature of SCD. The consistent results were collected from the articles included in this review to provide a comprehensive summary of common neuroimaging changes in SCD. a SCD individuals exhibit a pattern of amyloid accumulation within the medial prefrontal, cingulum and precuneus cortex, which are early sites of vulnerability in MCI and dementia due to AD. b The medial temporal lobe is frequently characterized by hypometabolism, whereas other studies have reported a strong association between SCD and hypometabolism within the precuneus. c Individuals with SCD showed decreased hippocampal volume and thinner entorhinal cortex than healthy controls. d The abnormal FC between the posterior DMN and other regions are frequently reported in resting-state fMRI studies. e DTI studies have reported decreased FA in hippocampal and parahippocampal white matter in SCD individuals. Abbreviations: SCD = Subjective cognitive decline; MCI = Mild cognitive impairment; AD = Alzheimer’s disease; DTI = Diffusion tensor imaging; DMN = Default mode network; fMRI = Functional MRI; FC=Functional connectivity