From: Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer’s disease
Authors | Definition of SCD | Modality | Design | Sample (mean age ± SD) | Main findings |
---|---|---|---|---|---|
Buckley et al. (2017) [190] | SCD composite questions | PiB-PET FTP-PET | Cross-sectional | All: n = 133 (75.9±7.0) Aß negative: n = 94 (74.9±7.2) Aß positive: n = 39 (78.4±5.7) | Greater SCD relate to increased entorhinal tau burden and Aß burden |
1 binary question | PiB-PET MRI | Cross-sectional | NC: n = 45 (74.9±7.1) SCI: n = 49 (73.9±7.2) MCI:n = 34 (75.4±7.2) AD: n = 35 (75.1±7.9) | Relation between global and regional atrophy and Aβ-amyloid load in SCI individuals but not in MCI or AD dementia | |
1 binary question | PiB-PET MRI | Cross-sectional | HC-: n = 32 (73.1±7.1) HC+: n = 13 (78.9±5.5) SCI-: n = 30 (72.1±7.1) SCI+: n = 19 (76.7±6.5) MCI+: n = 22 (75.8±7.1) AD+: n = 34 (75±7.9) | Larger temporal gray matter volume in HC with high amyloid load; gray matter atrophy in SCI with high amyloid load and MCI compared to HC | |
2 binary questions | 18F-florbetapir PET Rs-fMRI | Cross-sectional | Overall: n = 267 (75.8±3.5) ApoE ɛ4 noncarriers: n = 192 (75.7±3.6) ApoE ɛ4 carriers: n = 53 (76.1±3.6) | Higher SUVR values related to lower posterior basal forebrain RSFC in the hippocampus and the thalamus, impacted by sex and ApoE genotype | |
2 binary questions | 18F-florbetapir PET Rs-fMRI | Cross-sectional | All: n = 224 (75.5±3.4) ApoE ɛ4 noncarriers: n = 180 (75.5±3.4) ApoE ɛ4 carriers: n = 44 (75.6±3.5) | DMN changes in frontal and posterior areas and right hippocampus. No impact of brain amyloid load status on longitudinal RSFC. | |
Eliassen et al. (2017) [193] | Cognitive complaints | FDG-PET MRI | Cross-sectional | aMCI: n = 53(61.9±7.8) naMCI: n = 27(60.7±7.8) SCD: n = 38(59±8.3) | Lower cortical glucose metabolism in aMCI than SCD and controls. Thinner entorhinal cortex in SCD and aMCI |
Ferreira et al. (2017) [183] | 1 binary question | PiB-PET MRI | Cross-sectional | HC-like SMD: n = 75 (72.5±6.8) AD-like SMD: n = 11 (75.3±8.8) | The disease severity index identified eleven (13%) SCD with AD-like pattern of brain atrophy, who show lower cognitive performance, higher amyloid deposition, and worse clinical progression |
Gaubert et al. (2019) [189] | Memory complaint | 18F-florbetapir PET EEG | Cross-sectional | All: n = 314 (76.07±3.47) A-N-: n = 175 (75.62±3.39) A+N-: n = 63 (76.81±3.19) A+N+: n = 25 (76.88±4.01) | EEG metrics of fronto-central regions correlate with neurodegeneration. A U-shape or inverted U-shape relationships between amyloid burden and EEG metrics in neurodegeneration positive subjects |
Kramberger et al. (2017) [188] | Memory clinic consultation | EEG MRI | Cross-sectional | SCI: n = 194 (57.7±7.5) MCI: n = 141 (61.7±8.3) AD: n = 58 (63.6±7.0) | WMLs and medial temporal atrophy relate to slower BA in all diagnoses |
Kuhn et al. (2019) [192] | Composite of 10 questions CDS | 18F-florbetapir PET FDG-PET MRI | Longitudinal (15-43 months) | HC: n=28 (72.25±6.33) SCD-community: n = 23 (71.70±6.60) SCD-clinic: n = 27 (68.30±7,99) | Higher self-reported SCD relate to lower gray matter volume and higher anxiety in SCD-community, to greater informant-reported SCD in SCD-clinic and to lower glucose metabolism in both SCD groups |
Li et al. (2018) [187] | CCI | 18F-florbetapir PET MRI | Cross-sectional | NC: n = 40 (75.10±5.39) SMC: n = 44 (73.78±5.81) | Higher DC in the bilateral hippocampus and left fusiform gyrus and lower DC in inferior parietal in SMC. DC in bilateral hippocampus and left fusiform relate to total tau and phosphorylated tau, but not to amyloid deposition |
Scheef et al. (2012) [59] | Memory clinic consultation 2 binary questions | FDG-PET MRI | Cross-sectional | Controls: n = 56 (66.4±7.2) SMI: n = 31 (67.6±6.2) | Hypometabolism in right precuneus and hypermetabolism in right medial temporal and reduced gray matter volume in hippocampus in SMI group. Longitudinal memory decline relates to reduced glucose metabolism in right precuneus in SMI |
Shokouhi et al. (2019) [191] | E-Cog | 18F-flortaucipir PET 18F-florbetapir PET | Cross-sectional | All: n = 86 (78±8) | Tau pathology predict everyday planning in SCD, and amyloid pathology relate to everyday organization and memory in SCD |
Teipel et al. (2018) [178] | 2 binary questions | 18F-florbetapir PET MRI EEG | Cross-sectional | Amyloid negative: n = 63 (75.9±3.5) Amyloid positive: n = 255 (76.7±3.5) | No significant relationship between amyloid load and phase-lag index in any frequency band |
Teipel et al. (2017) [182] | 2 binary questions | 18F-florbetapir PET MRI | Cross-sectional | All: n = 318 (76.1±3.5) | Association between amyloid uptake and reduced gray matter structural integrity and poorer objective cognitive performance |
Ten Kate et al. (2018) [101] | 2 binary questions | 18F-florbetapir PET MRI | Cross-sectional | All: n=318(76 74±78) Amyloid-: n = 230 (76 73±78) Amyloid+: n = 88 (77 75±79) | Association between higher global SUVR and lower clustering, and small world values in orbito-and dorsolateral frontal and parietooccipital regions. |
Wirth et al. (2018) [184] | Memory clinic consultation | 18F-florbetapir PET MRI FDG-PET | Cross-sectional | HC: n=41 (66.1 ±7.7) ApoE ɛ4+: n = 17 (63.9±8.6) SCD: n=16 (68.9±7.3) MCI: n=30 (73.4±7.2) AD: n=22 (68.7±9.4) | (1) in medial-temporal regions, local gray matter volume reduction exceeded hypometabolism, (2) in temporoparietal regions, hypometabolism predominated over gray matter volume reduction, and (3) in frontal regions, Aβ deposition exceeded gray matter volume reduction and hypometabolism. Three distinct biomarker patterns in MCI, only pattern 1 in SCD, only pattern 3 in ApoE ɛ4 carriers |
Yasuno et al. (2015) [113] | EMC | PiB-PET MRI | Cross-sectional | nSCI: n = 30 (72.2±4.8) SCI: n = 23 (69.6±8.0) | Reduced FC in cortical midline structure in SCI. reduced WM connections relate to reduced FC. No amyloid deposition in SCI |