GSK1482160 treatment reduced accumulation of misfolded tau in P301S mouse brain. a-b. Alz50 staining (a) and quantification (b) in the hippocampal and cortical regions of mice ± GSK1482160 treatment. c-d. MC1 staining (c) and quantification (d) in the stratum radiatum of CA1 and mossy fibers of CA3 of the hippocampal regions. b, d: ***p < 0.001 and ****p < 0.0001 compared with WT + VEH group; #p < 0.05 and ##p < 0.01 compared with P301S + VEH group; n.s denotes no significance as determined by one-way ANOVA (alpha = 0.05) and Dunnett’s post-hoc. n = (6, 7, 7) mice for WT + VEH, P301S + VEH and P301S + GSK groups. Graphs indicate mean ± s.e.m.