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Fig. 12 | Molecular Neurodegeneration

Fig. 12

From: CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Fig. 12

The schematic diagram showing the timeline of the progression of glaucomatous neurodegeneration in mouse model of Dex-induced OHT. Dex treatment leads to significant IOP elevation starting from 1 week of injection, which is associated with reduced outflow facility. These changes are associated with ECM accumulation and increased cytoskeleton proteins in the TM. About 32% ON axonal loss and activation of astrocytes in ONH was observed at 5 weeks of Dex treatment. At this stage, we did not observe functional or structural loss of RGCs. Most of the CTB transport was active at this stage. At 8 and 10 weeks of treatment, there was 48 and 62% loss of optic nerve axons respectively. At this stage, significant structural (30–40%) and functional loss of RGCs was observed. We also observed complete blockage of axoplasmic transport along with activation of astrocytes and infiltration of immune cells

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Molecular Neurodegeneration

ISSN: 1750-1326