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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Fig. 2

Dex-induced OHT leads to functional and structural loss of RGCs in mice. C57BL/6 J mice were periocularly injected with Veh or Dex for 10 weeks and RGC functional loss was examined by PERG. Representative wave graphs are shown for Veh (a) and Dex (b) injected mice. PERG amplitude (c) and latency (d) demonstrated a significant functional loss of RGCs in Dex-injected mice as evident from reduced amplitudes with increased latencies. Data are shown as mean ± SD (n = 18 in Veh and n = 22 in Dex, unpaired t-test, two tailed, ***p < 0.0001). e Representative images of immunostaining of whole mount retina with RGC specific marker, RBPMS in periphery, mid-periphery and center of retinas of 10 weeks post Veh or Dex-injected mice. A significant loss of RGCs (33% loss) is observed in Dex-injected mice (f). Data are shown as mean ± SD (n = 22 in Veh and n = 18 in Dex, unpaired t-test, two tailed, **p = 0.004, ***p < 0.0001)

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Molecular Neurodegeneration

ISSN: 1750-1326