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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Fig. 5

Withdrawal of Dex results in IOP reduction and prevents Dex-induced RGC loss. Three-month old C57BL/6 J mice were injected bilaterally once a week for 5-weeks with either Veh or Dex. Dex-treated mice were randomly divided in two groups. Dex treatment was withdrawn in one group while another group continued to receive Dex for additional 5 weeks. a Weekly IOP measurements revealed sustained and significant IOP elevation in Dex-injected mice compared to Veh-injected mice. Withdrawal of Dex injections caused significant reduction of elevated IOP in Dex discontinued group. Data are shown as mean ± SD (n = 8 to 10 in each group, 2-WAY ANOVA with multiple comparison, #p < 0.0001). b Representative RBPMS stained whole mount retinal images and c total RGC quantitation revealed a significant loss of RGCs in 10 weeks Dex-injected mice while no RGC loss was observed in Dex discontinued mice compared to Veh injected mice. Data are shown as mean ± SD (n = 10 in Veh, n = 6 in Dex and n = 5 in Dex discontinued group, One WAY ANOVA with multiple comparison, *p = 0.03, ***p < 0.0001)

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