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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Fig. 8

Glaucomatous neurodegeneration is associated with activation of F4/80 positive macrophage-like cells. a&b 10 weeks Veh and Dex-injected eyes are enucleated, sectioned through ONH and analyzed for F4/80 positive cells by immunostaining. The corresponding images from 10 weeks post Dex-injected eyes showed an increased number of F4/80 positive macrophage-like cells at ONH compared to 10 weeks Veh injected eyes (n = 4). c&d For comparisons, a similar trend is observed in the human glaucomatous ONH, where the number of F4/80 positive macrophage-like cells expressing TNF-α (green) is significantly higher in glaucomatous ONH compared to age matched normal ONH (n = 4 in normal and n = 4 in glaucoma). Data are shown as mean ± SD (unpaired t-test, two tailed, **p = 0.002, ***p = 0.0007)

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